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W205702

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Ageliki Tsagaratou et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(32), E3306-E3315 (2014-07-30)
The discovery of Ten Eleven Translocation proteins, enzymes that oxidize 5-methylcytosine (5mC) in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell...
Leonardo Joaquim van Zyl et al.
Archives of virology, 160(9), 2269-2282 (2015-07-01)
The study of extremophilic phages may reveal new phage families as well as different mechanisms of infection, propagation and lysis to those found in phages from temperate environments. We describe a novel siphovirus, GVE3, which infects the thermophile Geobacillus thermoglucosidasius....
Nelson F Eng et al.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 26(3), 137-144 (2015-08-04)
Helicobacter pylori plays a significant role in gastritis and ulcers. It is a carcinogen as defined by the WHO, and infection can result in adenocarcinomas and mucosa-associated lymphoid tissue lymphomas. In Canada, rates of antimicrobial resistance are relatively unknown, with...
Schreiber Pereira et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(26), 9035-9044 (2012-06-30)
The nematode Caenorhabditis elegans can adapt to both the AWC-sensed odorants benzaldehyde (Bnz) and isoamyl alcohol (IsoA) and can reciprocally cross-adapt. Yet we reveal that these four adaptation scenarios actually represent two distinct forms of learning: nonassociative habituation and associative...
Young-Ran Song et al.
Food microbiology, 51, 171-178 (2015-07-19)
This study deals with understanding the effects of salt reduction on both the physicochemical and microbiological properties of soy sauce fermentation and also the application of indigenous yeast starters to compensate for undesirable changes occurring in salt-reduced processes. Fermentation was...
Vincent J Cannistraro et al.
The Journal of biological chemistry, 290(44), 26597-26609 (2015-09-12)
Sunlight-induced C to T mutation hot spots in skin cancers occur primarily at methylated CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation. The C and 5-methyl-C in CPDs are not stable and deaminate to U...
Niels O Verhulst et al.
Malaria journal, 10, 28-28 (2011-02-10)
Anopheles gambiae sensu stricto is considered to be highly anthropophilic and volatiles of human origin provide essential cues during its host-seeking behaviour. A synthetic blend of three human-derived volatiles, ammonia, lactic acid and tetradecanoic acid, attracts A. gambiae. In addition...
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)...
T Geetha et al.
Journal of drug targeting, 23(2), 159-169 (2014-10-01)
Abstract Role of reactive oxygen species (ROS) in skin carcinogenesis is well documented. Natural molecules, like sesamol, with marked antioxidant potential can be useful in combating skin cancers. In vitro antiproliferative (using MTT assay) and DNA fragmentation studies in HL...
D R Alves et al.
Applied and environmental microbiology, 80(21), 6694-6703 (2014-08-26)
Biofilms are major causes of impairment of wound healing and patient morbidity. One of the most common and aggressive wound pathogens is Staphylococcus aureus, displaying a large repertoire of virulence factors and commonly reduced susceptibility to antibiotics, such as the...
Nikki van Bel et al.
Virology, 483, 236-252 (2015-05-20)
The untranslated leader of the HIV-1 RNA genome is highly structured and contains multiple replication signals. We probed in detail the sequence requirements of a small single-stranded domain using a combination of in silico, in vitro and in vivo virus...
Luca Bianco et al.
PloS one, 9(10), e110377-e110377 (2014-10-11)
High-density SNP arrays for genome-wide assessment of allelic variation have made high resolution genetic characterization of crop germplasm feasible. A medium density array for apple, the IRSC 8K SNP array, has been successfully developed and used for screens of bi-parental...
Helene Wiebe et al.
Journal of bacteriology, 197(16), 2713-2720 (2015-06-17)
The presumptive transcriptional regulator YjjQ has been identified as being virulence associated in avian pathogenic Escherichia coli (APEC). In this work, we characterize YjjQ as transcriptional repressor of the flhDC operon, encoding the master regulator of flagellar synthesis, and of...
Marcin Dembek et al.
mBio, 6(2), e02383-e02383 (2015-02-26)
Clostridium difficile is the most common cause of antibiotic-associated intestinal infections and a significant cause of morbidity and mortality. Infection with C. difficile requires disruption of the intestinal microbiota, most commonly by antibiotic usage. Therapeutic intervention largely relies on a small...
Miklós Tóth et al.
Journal of chemical ecology, 36(6), 592-598 (2010-05-08)
In field tests in Europe, traps baited with a blend of isoamyl alcohol, acetic acid, and isobutanol (compounds previously found attractive to a number of noctuids in North America) caught the following noctuid moths: Agrotis segetum Schiff., Agrotis crassa Hbn....
Olatz Albaina et al.
Journal of medical microbiology, 64(Pt 2), 147-156 (2014-12-07)
Candida dubliniensis is a pathogenic yeast of the genus Candida closely related to Candida albicans. The phenotypic similarity of these two species often leads to misidentification of C. dubliniensis isolates in clinical samples. DNA-based methods continue to be the most...
Amir Sherman et al.
BMC plant biology, 15, 277-277 (2015-11-18)
Germplasm collections are an important source for plant breeding, especially in fruit trees which have a long duration of juvenile period. Thus, efforts have been made to study the diversity of fruit tree collections. Even though mango is an economically...
Zhi Zou et al.
BMC genomics, 16, 1001-1001 (2015-11-27)
Natural rubber, an important industrial raw material, is specifically synthesized in laticifers located inside the rubber tree (Hevea brasiliensis Muell. Arg.) trunk. Due to the absence of plasmodesmata, the laticifer water balance is mediated by aquaporins (AQPs). However, to date...
H Ando et al.
Journal of applied microbiology, 118(4), 873-880 (2015-01-30)
To evaluate the antimicrobial properties of the main Ginjo-flavour components of sake, volatile isoamyl acetate and isoamyl alcohol. Volatile isoamyl acetate and isoamyl alcohol both inhibited growth of the five yeast and 10 bacterial test strains. The minimum inhibitory dose...
K V Greco et al.
Journal of biomaterials applications, 30(2), 239-253 (2015-04-10)
Off-the-shelf availability of tissue-engineered skin constructs, tailored by different combinations of reagents to produce a highly preserved biological matrix is often the only means to help patients suffering skin damage. This study assessed the effect of five different decellularisation methods...
Daisuke Ikeue et al.
Plant methods, 11, 34-34 (2015-06-09)
The genus Cuscuta is a group of parasitic plants that are distributed world-wide. The process of parasitization starts with a Cuscuta plant coiling around the host stem. The parasite's haustorial organs then establish a vascular connection allowing for access to...
Jean-Rémi Bertrand et al.
Nucleic acid therapeutics, 25(3), 121-129 (2015-04-22)
Covalent binding of squalene to siRNA has already been shown to be an interesting way of delivering siRNA in vivo. Whether squalene derivatives could also be used to deliver siRNA in cells without covalent binding similar to usual transfection with...
Simone Freiding et al.
Systematic and applied microbiology, 34(5), 311-320 (2011-05-17)
A total of 51 Lactobacillus sakei and 28 Lactobacillus curvatus strains from different origins were screened for their potential to produce biogenic amines (BAs), and for their diversity of peptidolytic systems and specific aminotransferases (AraT, BcaT) that initiate amino acid...
Heather M Wilkins et al.
Journal of Alzheimer's disease : JAD, 45(1), 305-318 (2014-12-30)
Neuroinflammation occurs in Alzheimer's disease (AD). While AD genetic studies implicate inflammation-relevant genes and fibrillar amyloid-β protein promotes inflammation, our understanding of AD neuroinflammation nevertheless remains incomplete. In this study we hypothesized damage-associated molecular pattern (DAMP) molecules arising from mitochondria...
Eun Ji Joo et al.
Chemico-biological interactions, 233, 25-34 (2015-04-01)
Ginsenoside Rg3 (Rg3), a pharmacologically active compound from red ginseng, has been reported to induce cell death in various cancer cell lines, although the specific mechanisms have not been well established. In the present study, Rg3 treatment to A549 human...
Simon P Jochems et al.
Journal of virology, 89(13), 6918-6927 (2015-04-24)
Human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques (MAC) lead to chronic inflammation and AIDS. Natural hosts, such as African green monkeys (AGM) and sooty mangabeys (SM), are protected against SIV-induced chronic inflammation and AIDS....
Anne Benard et al.
Apoptosis : an international journal on programmed cell death, 19(12), 1769-1778 (2014-10-09)
The apoptosis pathway of programmed cell death is frequently deregulated in cancer. An intact apoptosis pathway is required for proper response to anti-cancer treatment. We investigated the chromatin status of key apoptosis genes in the apoptosis pathway in colorectal cancer...
Yaoguo Li et al.
Fish & shellfish immunology, 45(2), 912-918 (2015-06-21)
Galectin is one important member of pattern recognition proteins that plays a pivotal role in regulating innate immune response of invertebrates. In this study, we cloned the promoter sequence of a tandem-repeat galectin from the pearl oyster Pinctada fucata (P....
Keerti Potluri et al.
Analytical biochemistry, 486, 17-23 (2015-07-02)
As new technologies come within reach for the average cytogenetic laboratory, the study of chromosome structure has become increasingly more sophisticated. Resolution has improved from karyotyping (in which whole chromosomes are discernible) to fluorescence in situ hybridization and comparative genomic...
Rwik Sen et al.
Nucleic acids research, 42(15), 9892-9907 (2014-08-13)
Rrd1p (resistance to rapamycin deletion 1) has been previously implicated in controlling transcription of rapamycin-regulated genes in response to rapamycin treatment. Intriguingly, we show here that Rrd1p associates with the coding sequence of a galactose-inducible and rapamycin non-responsive GAL1 gene...
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