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Abdul Bari et al.
Journal of microencapsulation, 32(1), 54-60 (2014-08-05)
The objective of the present study was to improve solubility, dissolution rate and therapeutic efficacy of a BCS Class II drug, glibenclamide by using oral self nano emulsifying powder. The powder was prepared by adsorbing the mixture of oil, surfactant
Paul A Turner et al.
Tissue engineering. Part A, 21(11-12), 1837-1847 (2015-03-18)
To improve treatment of obesity, a contributing factor to multiple systemic and metabolic diseases, a better understanding of metabolic state and environmental stress at the cellular level is essential. This work presents development of a three-dimensional (3D) in vitro model
Nitro-oleic acid is a novel anti-oxidative therapy for diabetic kidney disease.
Madhav C Menon et al.
American journal of physiology. Renal physiology, 305(11), F1542-F1543 (2013-09-21)
M D Jensen
The Journal of clinical investigation, 96(5), 2297-2303 (1995-11-01)
These studies were conducted to determine whether men and women differ with regards to their overnight postabsorptive (basal) and postprandial fatty acid kinetics. Systemic oleate turnover ([9,10(3)H]oleate) was measured before and after the consumption of a mixed meal. Leg and
C Carrillo et al.
Nutricion hospitalaria, 27(6), 1860-1865 (2013-04-17)
The beneficial effects of oleic acid in cancer processes can no longer be doubted, but little is known about the mechanisms of action behind this phenomenon. The aim of the present review is to clarify whether oleic acid has an
Ana G Ramos-Martínez et al.
Experimental lung research, 41(1), 1-11 (2014-10-03)
Explore the temporal expression of metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) during experimental tuberculosis induced by virulent Mycobacterium tuberculosis strain H37Rv. BALB/c mice were infected via endotracheal instillation with H37Rv. Groups of mice were euthanized at different time
Karen Kleberg et al.
The Journal of physiology, 593(8), 2097-2109 (2015-02-03)
Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensing to food intake and the activation of brain circuits remain to be identified. In this
Chiara Ingrosso et al.
ACS applied materials & interfaces, 7(28), 15494-15505 (2015-07-08)
A novel UV-light-curable nanocomposite material formed of a methacrylic-siloxane resin loaded with 1 wt % oleic acid and 3-(trimethoxysilyl)propyl methacrylate silane (OLEA/MEMO)-coated TiO2 nanorods (NRs) has been manufactured as a potential self-curing structural coating material for protection of monuments and
Michael C Rudolph et al.
Journal of lipid research, 55(6), 1052-1065 (2014-04-29)
Thyroid hormone responsive protein Spot 14 has been consistently associated with de novo fatty acid synthesis activity in multiple tissues, including the lactating mammary gland, which synthesizes large quantities of medium chain fatty acids (MCFAs) exclusively via FASN. However, the
Lin Han et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11981-11987 (2014-06-28)
Phase transfer techniques possess remarkable advantages for the synthesis of inorganic nanomaterials. In contrast to the abundant reports on the preparation of noble metal nanoparticles using phase transfer, the number of semiconductor nanocrystals syntheses based on phase transfer techniques is
Song Ye et al.
Dalton transactions (Cambridge, England : 2003), 44(35), 15583-15590 (2015-08-06)
The pH value plays an important role in controlling the crystallization process and microstructure of the final products in the synthesis of nanocrystals with a solvothermal method. This work reported the effect of the mother solution pH value on the
Comparison of oxidative stability of high-and normal-oleic peanut oils.
O?keefe SF, et al.
Journal of the American Oil Chemists' Society, 70(5), 489-492 (1993)
Chieko Iwao et al.
PloS one, 10(7), e0132761-e0132761 (2015-07-18)
The acyclic diterpenoid acid geranylgeranoic acid (GGA) has been reported to induce autophagic cell death in several human hepatoma-derived cell lines; however, the molecular mechanism for this remains unknown. In the present study, several diterpenoids were examined for ability to
Juan L Benedé et al.
Talanta, 147, 246-252 (2015-11-26)
In this work, a new approach that combines the advantages of stir bar sorptive extraction (SBSE) and dispersive solid phase extraction (DSPE), i.e. stir bar sorptive-dispersive microextraction (SBSDµE), is employed as enrichment and clean-up technique for the sensitive determination of
Xuping Wang et al.
Biochemical and biophysical research communications, 460(2), 392-396 (2015-03-19)
More and more industrial chemistry reactions rely on green technologies. Enzymes are finding increasing use in diverse chemical processes. Epoxidized vegetable oils have recently found applications as plasticizers and additives for PVC production. We report here an unusual activity of
Genetic control of high oleic acid content in sunflower oil.
Miller JF, et al.
Crop Science, 27(5), 923-926 (1987)
Suzanne M Caliph et al.
The Journal of pharmacy and pharmacology, 66(10), 1377-1387 (2014-05-14)
To assess the role of intestinal lymphatic transport in the oral bioavailability and brain deposition of a highly lipophilic, centrally acting drug candidate (Org 49209) in comparison to cholesterol, a close structural analogue. The intestinal lymphatic transport of Org 49209
Michael Chorny et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(6), 2198-2206 (2013-02-15)
Gene therapeutic strategies have shown promise in treating vascular disease. However, their translation into clinical use requires pharmaceutical carriers enabling effective, site-specific delivery as well as providing sustained transgene expression in blood vessels. While replication-deficient adenovirus (Ad) offers several important
Jing Tang et al.
Nanoscale, 7(35), 14752-14759 (2015-08-20)
Red upconversion luminescence (UCL) is selectively enhanced by about 7 times via Fe(3+) codoping into a NaYF4:Yb,Er nanocrystalline lattice. The maximum red-to-green ratio (R/G) as well as the overall integrated UCL intensity features at an Fe(3+) content of 20 mol%.
Natalia Rueda-Rincon et al.
Oncotarget, 6(25), 21240-21254 (2015-06-11)
The p53 tumor suppressor is the central component of a complex network of signaling pathways that protect organisms against the propagation of cells carrying oncogenic mutations. Here we report a previously unrecognized role of p53 in membrane phospholipids composition. By
Angelo Fontana et al.
Biochimica et biophysica acta, 1834(6), 1125-1143 (2013-03-19)
A complex formed by human α-lactalbumin (α-LA) and oleic acid (OA), named HAMLET, has been shown to have an apoptotic activity leading to the selective death of tumor cells. In numerous publications it has been reported that in the complex
Audrey Bergouignan et al.
The American journal of clinical nutrition, 98(3), 648-658 (2013-08-02)
Previous studies suggested that physical activity energy expenditure (AEE) is a major determinant of dietary fat oxidation, which is a central component of fat metabolism and body weight regulation. We tested this hypothesis by investigating the effect of contrasted physical
Ching-Wan Lam et al.
Journal of proteome research, 13(9), 4040-4046 (2014-08-15)
Untargeted mass spectrometry-based metabolomic profiling is a powerful analytical method used for broad-spectrum identification and quantification of metabolites in biofluids in human health and disease states. In this study, we exploit metabolomic profiling for cancer biomarker discovery for diagnosis of
Aaron T Wecksler et al.
Bioorganic & medicinal chemistry, 17(18), 6534-6539 (2009-09-01)
Recently, it has been shown that lipoxygenase (LO) products affect the substrate specificity of human 15-LO. In the current paper, we demonstrate that soybean LO-1 (sLO-1) is not affected by its own products, however, inhibitors which bind the allosteric site
Bruna Corominas-Faja et al.
Oncotarget, 5(18), 8306-8316 (2014-09-24)
Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth. We examined the anti-CSC effects of the antifungal polyketide soraphen A, a specific inhibitor of
Yuan Z Feng et al.
American journal of physiology. Cell physiology, 308(7), C548-C556 (2015-01-23)
Exercise improves insulin sensitivity and oxidative capacity in skeletal muscles. However, the effect of exercise on substrate oxidation is less clear in obese and type 2 diabetic subjects than in lean subjects. We investigated glucose and lipid metabolism and gene
Karen J Kieser et al.
PLoS pathogens, 11(6), e1005010-e1005010 (2015-06-27)
Cell growth and division are required for the progression of bacterial infections. Most rod-shaped bacteria grow by inserting new cell wall along their mid-section. However, mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce new cell wall material at their poles.
Meshail Okla et al.
Lipids, 50(2), 111-120 (2014-12-24)
Adult humans have a substantial amount of inducible-brown (or beige) fat, which is associated with increased energy expenditure and reduced weight gain via thermogenesis. Despite the identification of key regulators of beige adipogenesis, impacts of dietary factors on adaptive thermogenesis
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Marco Ruggiero et al.
Anticancer research, 34(7), 3569-3578 (2014-07-02)
Oleic Acid (OA) has been shown to have anticancer properties mediated by interaction with proteins such as α-lactalbumin and lactoferrins. Therefore, we synthesized complexes of OA and Gc protein-derived macrophage activating factor (GcMAF) that inhibits per se cancer cell proliferation
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