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W332615

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Ilona Olędzka et al.
Journal of pharmaceutical and biomedical analysis, 102, 45-53 (2014-09-23)
The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully...
Yunqing Zhu et al.
ACS nano, 8(7), 6644-6654 (2014-06-17)
The facile loading of sensitive and fragile biomacromolecules, such as glucose oxidase, hemoglobin, and ribonucleic acid (RNA), via synthetic vehicles directly in pure aqueous media is an important technical challenge. Inspired by the nucleus pore complex that connects the cell...
Janet van Eersel et al.
Neuropathology and applied neurobiology, 41(7), 906-925 (2015-03-13)
Tau becomes hyperphosphorylated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-tau), resulting in functional deficits of neurones, neurofibrillary tangle (NFT) formation and eventually dementia. Expression of mutant human tau in the brains of transgenic mice has produced different lines...
Piers R Boshier et al.
The Journal of surgical research, 193(2), 704-712 (2014-10-06)
Esophagectomy and gastrectomy are associated with profound metabolic changes and significant postoperative morbidity. The aim of this prospective clinical study was to determine whether breath analysis can offer novel insight into the surgical metabolic response and identify biomarkers of postoperative...
Agnieszka Śmieszek et al.
BioMed research international, 2015, 769402-769402 (2015-06-13)
Metformin, a popular drug used to treat diabetes, has recently gained attention as a potentially useful therapeutic agent for treating cancer. In our research metformin was added to in vitro cultures of bone marrow-derived multipotent mesenchymal stromal cells (BMSCs) and...
Chihiro Shimizuhira et al.
The Journal of investigative dermatology, 134(11), 2709-2718 (2014-04-24)
Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. Here, we...
Timothy R DeGrado et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1348-1354 (2014-07-23)
Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive imaging method for monitoring zinc in the body would be useful to understand zinc dynamics in health and disease. To provide a PET imaging agent for zinc, we...
Anna H Le et al.
PloS one, 9(8), e106013-e106013 (2014-08-26)
Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management...
Julia M Lewis et al.
The Journal of investigative dermatology, 135(5), 1405-1414 (2014-09-19)
Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled...
Seung Heon Lee et al.
Toxicology and applied pharmacology, 285(3), 159-169 (2015-04-23)
Cytochrome P450 (CYP) 1A1 is a heme-containing enzyme involved in detoxification of hydrophobic pollutants. Its Ala62Pro variant has been identified previously. Ala62 is located in α-helix A of CYP1A1. Residues such as Pro and Gly are α-helix breakers. In this...
Petr Tůma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)
Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in...
Sourav Roy et al.
PLoS genetics, 11(8), e1005450-e1005450 (2015-08-15)
In multicellular organisms, development, growth and reproduction require coordinated expression of numerous functional and regulatory genes. Insects, in addition to being the most speciose animal group with enormous biological and economical significance, represent outstanding model organisms for studying regulation of...
Manouela V Valtcheva et al.
The journal of pain : official journal of the American Pain Society, 16(4), 346-356 (2015-02-03)
Chronic pruritic conditions are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of acetone and ether followed by water (AEW) to the cheek skin of mice produced persistent scratching behavior with no...
Elisabeth Lenz et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 44-52 (2015-07-22)
Co-amorphous drug formulations provide the possibility to stabilize a drug in its amorphous form by interactions with low molecular weight compounds, e.g. amino acids. Recent studies have shown the feasibility of spray drying as a technique to manufacture co-amorphous indomethacin-arginine...
Sae-Rom Yoo et al.
International journal of clinical and experimental medicine, 8(6), 8698-8708 (2015-08-27)
Here we report in vitro anti-adipogenic and antioxidant effects of Samchulgeonbi-tang (SCGBT), a traditional Korean herbal formula. 3T3-L1 preadipocytes were differentiated into adipocytes with or without SCGBT. After differentiation, we measured Oil Red O staining, glycerol-3-phosphate dehydrogenase (GPDH) activity and...
Tahseen H Nasti et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2683-2695 (2015-02-20)
Prevention of tumors induced by environmental carcinogens has not been achieved. Skin tumors produced by polyaromatic hydrocarbons, such as 7,12-dimethylbenz(a)anthracene (DMBA), often harbor an H-ras point mutation, suggesting that it is a poor target for early immunosurveillance. The application of...
Zemin Xu et al.
Journal of hazardous materials, 295, 37-42 (2015-04-17)
To assess microbial degradation of alpha-cypermethrin in soil, attenuation of alpha-cypermethrin was investigated by compound-specific stable isotope analysis. The variations of the residual concentrations and stable carbon isotope ratios of alpha-cypermethrin were detected in unsterilized and sterilized soils spiked with...
Samaneh Mashaghi et al.
Scientific reports, 5, 11837-11837 (2015-07-03)
Scale reduction of chemical reactions enables novel screening and synthesis approaches that facilitate a highly parallelized and combinatorial exploration of chemical space. Droplet-based microfluidics have evolved as a powerful platform to allow many chemical reactions within small volumes that each...
Maria Margalef et al.
Journal of agricultural and food chemistry, 63(45), 9996-10003 (2015-10-27)
After ingestion flavanols are metabolized by phase-II enzymes and the microbiota and are distributed throughout the body depending on several factors. Herein we aim to evaluate whether flavanols are tissue-accumulated after the long-term administration of a grape seed polyphenol extract...
Sapan Kumar Sharma et al.
International journal of medicinal mushrooms, 17(7), 661-669 (2015-11-13)
In this study, using standard methods, mycelial nutrients, bioactive compounds, and antioxidants were analyzed for the first time for five fungal species: Isaria sinclairii (Berk.) Lloyd, I. tenuipes Peck, I. japonica Yasuda, I. farinosa (Holmsk) Fr. and Cordyceps tuberculata (Lebert)...
Zu-Long Sheng et al.
American journal of translational research, 7(6), 1045-1057 (2015-08-19)
This study determines whether preconditioning (PC) of human endothelial progenitor cells (hEPCs) with bradykinin promotes infarcted myocardium repair via enhanced activation of B2 receptor (B2R)-dependent Akt/eNOS and increased angiogenesis. hEPCs with or without bradykinin preconditioning (BK-PC) were transplanted into a...
Emma Kettle et al.
Traffic (Copenhagen, Denmark), 16(11), 1174-1192 (2015-09-25)
Cytokinesis is the final stage of cell division and produces two independent daughter cells. Vesicles derived from internal membrane stores, such as the Golgi, lysosomes, and early and recycling endosomes accumulate at the intracellular bridge (ICB) during cytokinesis. Here, we...
M Y Khuhawar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 873(1), 15-19 (2008-09-02)
Capillary gas chromatographic (GC) determination of methylglyoxal (MGo) was developed on the basis of precolumn derivatization with 1,2-diaminopropane (DAP) at pH 3. The elution was carried out on an HP-5 (30 m x 0.32 mm i.d.) connected with FID. The...
Waziha Farha et al.
Biomedical chromatography : BMC, 29(12), 1932-1936 (2015-06-03)
Perilla leaves contain many interfering substances; thus, it is difficult to protect the analytes during identification and integration. Furthermore, increasing the amount of sample to lower the detection limit worsens the situation. To overcome this problem, we established a new...
Eri Nakahara et al.
Journal of neuroimmunology, 285, 150-155 (2015-07-23)
We assessed the validity of immunoblotting, immunohistochemistry (IHC), and immunocytochemistry (ICC) to detect anti-neuronal antibodies in an attempt to establish a diagnostic approach for pediatric autoimmune encephalitis. Both IHC and ICC had higher sensitivity than immunoblotting and could differentiate between...
Franziska Heydebreck et al.
Environmental science & technology, 49(14), 8386-8395 (2015-06-25)
The production and use of long-chain perfluoroalkyl substances (PFASs) must comply with national and international regulations. Driven by increasingly stringent regulations, their production has been outsourced to less regulated countries in Asia. In addition, the fluoropolymer industry started to use...
Zohreh Majidnia et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 105, 105-113 (2015-08-16)
In this paper, both maghemite (γ-Fe2O3) and titanium oxide (TiO2) nanoparticles were synthesized and mixed in various ratios and embedded in PVA and alginate beads. Batch sorption experiments were applied for removal of barium ions from aqueous solution under sunlight...
Marta Maciejewska et al.
Antonie van Leeuwenhoek, 107(2), 519-531 (2014-12-11)
A novel actinobacterium, designated MM109(T), was isolated from a moonmilk deposit collected from the cave 'Grotte des Collemboles' located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, morphological, and physiological characterization, the isolate has been affiliated...
Laura Barp et al.
Analytica chimica acta, 887, 237-244 (2015-09-01)
Phthalates are a group of synthetic compounds mainly used as plasticizers, which have been classified as endocrine-disrupting chemicals and potential human-cancer causing agents. They can be found in high amounts in foods, deriving mainly from plastic packaging. The analytical determination...
Melissa Paoloni et al.
PloS one, 10(6), e0129954-e0129954 (2015-06-20)
Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as anti-cancer agent. Systemic administration of IL-12 often results in unacceptable toxicity; therefore, strategies to direct delivery of IL-12 to...
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