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xanthohumol

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Simon Roehrer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1095, 39-49 (2018-07-28)
Hop has been attracting scientific attention due to its favorable bioactivity properties. It is thus desirable to relate these properties to the specific hop compounds and extract these compounds in highly purified form in order to enhance the effect. The...
Lisa Rancán et al.
The Journal of nutritional biochemistry, 49, 133-140 (2017-09-28)
It has been recently shown that xanthohumol, a flavonoid present in hops, possesses antioxidant, anti-inflammatory and chemopreventive properties. However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective...
Daniel Walden et al.
Oncotarget, 8(50), 88069-88078 (2017-11-21)
Cholangiocarcinoma remains the second most prevalent hepatic neoplasm in the United States with a 5-year survival rate of less than 10%. Currently, no systemic therapy has demonstrated efficacy. Therefore, an urgent need for the identification of molecularly targeted compound(s) remains....
Pavel Cermak et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 125(11), 1033-1038 (2017-09-30)
Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C. difficile infection is problematic, making it imperative to search...
Weiliang Jiang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 73, 40-47 (2015-07-28)
Pancreatic cancer (PC) is one of the most lethal human malignancies worldwide. Here, we demonstrated that xanthohumol (XN), the most abundant prenylated chalcone isolated from hops, inhibited the growth of cultured PC cells and their subcutaneous xenograft tumors. XN treatment...
Wenbin Liu et al.
International journal of biological sciences, 15(11), 2497-2508 (2019-10-09)
Deregulation of glycolysis is a common phenomenon in human colorectal cancer (CRC). In the present study, we reported that Hexokinase 2 (HK2) is overexpressed in human CRC tissues and cell lines, knockout of HK2 inhibited cell proliferation, colony formation, and...
Jian Yuan et al.
Journal of Cancer, 11(14), 4047-4058 (2020-05-06)
Deregulation of aerobic glycolysis is a common phenomenon in human cancers, including glioblastoma (GBM). In the present study, we demonstrated that the natural compound xanthohumol has a profound anti-tumor effect on GBM via direct inhibition of glycolysis. Xanthohumol suppressed cell...
Cristina Fernández-García et al.
European journal of nutrition, 58(2), 653-663 (2018-03-15)
Aging is associated with a deregulation of biological systems that lead to an increase in oxidative stress, inflammation, and apoptosis, among other effects. Xanthohumol is the main preylated chalcone present in hops (Humulus lupulus L.) whose antioxidant, anti-inflammatory and chemopreventive...
Monika Stompor et al.
Journal of agricultural and food chemistry, 63(30), 6749-6756 (2015-07-16)
Xanthohumol (14) and isoxanthohumol (6) derived from hop (Humulus lupulus L., Cannabaceae) and selected chalcone and chromene derivatives, obtained by chemical synthesis, were studied for antifeedant activity against the peach-potato aphid (Myzus persicae [Sulz.]). The study used also commercially available...
Jae-Min Cho et al.
Oncotarget, 9(1), 866-880 (2018-02-09)
Xanthohumol (XN), a prenylated chalcone isolated from the hop plant, has been reported to exhibit multiple biological functions including anti-inflammation. However, the pharmacological function of XN on colitis remains unknown. In this study, we investigated the anti-inflammatory effect of synthesized...
Che Chuan Wang et al.
Neurochemistry international, 133, 104629-104629 (2019-12-10)
Excitotoxicity induced by excessive glutamate has been implicated in many brain disorders. Xanthohumol is a natural product derived from hops (Humulus lupulus L.), which is reported to have glutamate release-inhibiting activity. However, it is unknown whether xanthohumol has protective effects...
Christoph Dorn et al.
International journal of clinical and experimental pathology, 5(1), 29-36 (2012-02-02)
Xanthohumol, the major prenylated chalcone found in hops, is known for its anti-inflammatory properties. We have recently shown that xanthohumol inhibits hepatic inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis. The aim of this study was to investigate...
Ming Li et al.
Journal of experimental & clinical cancer research : CR, 39(1), 88-88 (2020-05-16)
Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventions. A natural product library was used for natural compound screening...
Xuxiu Lu et al.
Antioxidants (Basel, Switzerland), 8(9) (2019-09-19)
BCR-ABL oncoprotein drives the initiation, promotion, and progression of chronic myelogenous leukemia (CML). Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical application and prognosis. A novel promising therapeutic strategy for...
Ana Correia-Branco et al.
Reproductive sciences (Thousand Oaks, Calif.), 25(9), 1394-1405 (2017-12-15)
We previously described a negative effect of xanthohumol (XN) upon placentation-related processes. We aimed to better characterize this effect by investigating the effect of XN upon the uptake of arachidonic acid (ARA), a crucial nutrient during pregnancy, by the HTR-8/SVneo...
Yang Jiao et al.
Molecular biology reports, 47(4), 2417-2425 (2020-02-29)
Treatment of antioxidants is necessary to protect ischemic stroke associated neuronal damage. Xanthohumol (XN), a natural flavonoid extracted from hops, has been reported to have potential function as an antioxidant and can be used for neuro protection. However, the role...
Alessandra Scagliarini et al.
Cells, 9(4) (2020-04-16)
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low success rate in the treatment of CRC results from many failures associated...
Hiroshi Hirata et al.
The Journal of nutritional biochemistry, 47, 29-34 (2017-05-16)
Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important...
Mário Lima-Fontes et al.
Journal of agricultural and food chemistry, 65(34), 7433-7439 (2017-07-27)
Diabetes exhibits increased inflammation, angiogenesis, and apoptosis, three processes attenuated by xanthohumol (XN). Herein, we evaluate the effect of XN-enriched stout beer consumption in hepatic glucolipid metabolism imbalance seen in type 1 diabetes (T1D). Five groups of Wistar rats were...
Feifei Bai et al.
ACS chemical neuroscience, 10(6), 2956-2966 (2019-05-23)
The nuclear factor erythroid 2-related factor 2 (Nrf2), a master transcription factor controlling a series of cytoprotective genes, is closely associated with scavenging the reactive oxygen species and maintaining the intracellular redox balance. Accumulating evidence has indicated that activation of...
Hongming Lv et al.
Redox biology, 12, 311-324 (2017-03-13)
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injury (ALI). Xanthohumol (Xn), a...
Abdo Mahli et al.
Cells, 8(4) (2019-04-20)
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether...
Adrianna Sławińska-Brych et al.
Biochimica et biophysica acta. General subjects, 1863(11), 129408-129408 (2019-08-07)
Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert anticancer effects on various cancer types. However, the mechanisms by which XN affects the survival of multiple myeloma cells (MM) are little known. Therefore, our study was undertaken to address this...
Peng-Hsu Chen et al.
Neuropharmacology, 110(Pt A), 362-375 (2016-08-04)
Xanthohumol (XN), a prenylated chalcone extracted from hop plant Humulus lupulus L. (Cannabaceae), has potential for cancer therapy, including gliomas. Micro (mi)RNAs are small noncoding RNAs that control gene expression. Several miRNAs have been identified to participate in regulating glioma...
Yi-Ming Zhang et al.
Journal of Asian natural products research, 22(9), 850-863 (2019-07-28)
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum...
Boguslawa Luzak et al.
Archives of physiology and biochemistry, 123(1), 54-60 (2016-11-20)
Hop cones (Humulus lupulus L.), very rich source of phenolic compounds, possessing anticancer, antioxidant and anti-inflammatory activities, are considered as beneficial diet ingredients improving human health. In this study, the antiplatelet action of xanthohumol (XN), the principal flavonoid in hop...
Kuo-Hao Ho et al.
Life sciences, 254, 117807-117807 (2020-05-19)
Xanthohumol (XN), a natural prenylated flavonoid isolated from Humulus lupulus L. (hops), possess the therapeutic effects in glioblastoma multiforme (GBM), which is a grade IV aggressive glioma in adults. However, low bioavailability and extractive yield limit the clinical applications of...
Adrianna Sławińska-Brych et al.
Chemico-biological interactions, 240, 110-118 (2015-08-25)
Xanthohumol (XN), a prenylflavonoid derived from the hop plant (Humulus lupulus L.) has been found to exhibit a broad spectrum of biological properties, including anti-cancer activity. In this study, the mechanisms involved in anti-cancer activity of XN in human RK33...
Shingo Miyata et al.
The Journal of biological chemistry, 290(33), 20565-20579 (2015-07-05)
Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP inactivator that reduces...
Janaiya S Samuels et al.
Nutrition & metabolism, 15, 42-42 (2018-06-28)
Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. Various phytochemicals have been reported to contribute to the beiging of white adipose tissue in order to ameliorate obesity by increasing thermogenesis....
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