Showing 1-17 of 17 results for "XNAT2R"
Jeffrey J Dehmer et al.
PloS one, 6(11), e27070-e27070 (2011-11-22)
Murine small intestinal crypt development is initiated during the first postnatal week. Soon after formation, overall increases in the number of crypts occurs through a bifurcating process called crypt fission, which is believed to be driven by developmental increases in...
Nikki A Ford et al.
International journal of cancer, 131(2), E143-E148 (2011-09-22)
Lycopene, the red pigment of tomatoes, is hypothesized to reduce prostate cancer risk, a disease strongly dependent upon testosterone. In this study, mice lacking the expression of carotene-15,15'-monooxygenase (CMO-I(-/-) ) or wild-type mice were fed either a 10% tomato powder...
Xiaodong Sun et al.
Cell cycle (Georgetown, Tex.), 12(7), 1133-1141 (2013-03-09)
Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor in certain types of cancer. It remains unknown whether parkin is involved in the development...
Giuseppe Sciamanna et al.
PloS one, 6(9), e24261-e24261 (2011-09-14)
DYT1 dystonia, a severe form of genetically determined human dystonia, exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence and variability remain unclear. We characterized the alterations in D2 dopamine receptor (D2R) signalling...
Graziella Madeo et al.
Movement disorders : official journal of the Movement Disorder Society, 29(1), 41-53 (2013-10-30)
Homozygous or compound heterozygous mutations in the phosphatase and tensin homolog-induced putative kinase 1 (PINK1) gene are causative of autosomal recessive, early onset Parkinson's disease. Single heterozygous mutations have been detected repeatedly both in a subset of patients and in...
Giuseppina Martella et al.
Brain : a journal of neurology, 132(Pt 9), 2336-2349 (2009-07-31)
DYT1 dystonia is a severe form of inherited dystonia, characterized by involuntary twisting movements and abnormal postures. It is linked to a deletion in the dyt1 gene, resulting in a mutated form of the protein torsinA. The penetrance for dystonia...
Giuseppe Sciamanna et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(35), 11991-12004 (2012-08-31)
Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic interneurons. These neurons respond with a pause in their pacemaking activity, enabling synaptic integration with cortical inputs to medium spiny neurons (MSNs), thus playing a crucial role in motor...
Erin C Zook et al.
Blood, 118(22), 5723-5731 (2011-09-13)
The forkhead box n1 (Foxn1) transcription factor is essential for thymic organogenesis during embryonic development; however, a functional role of Foxn1 in the postnatal thymus is less well understood. We developed Foxn1 transgenic mice (Foxn1Tg), in which overexpression of Foxn1...
Gergely Vida et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(12), 4476-4485 (2011-08-16)
The nervous system is classically organized into sympathetic and parasympathetic systems acting in opposition to maintain physiological homeostasis. Here, we report that both systems converge in the activation of β2-adrenoceptors of splenic regulatory lymphocytes to control systemic inflammation. Vagus nerve...
Chelsea D Mullins et al.
PloS one, 8(6), e67941-e67941 (2013-07-05)
Activating mutations in Ras (N- and K-) are the most common point mutations found in patients with multiple myeloma (MM) and are associated with poor clinical outcome. We sought to directly examine the role of Ras activation in MM pathogenesis...
Laura Pontano Vaites et al.
Molecular and cellular biology, 31(22), 4513-4523 (2011-09-14)
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorigenesis, and...
Theresa A Harrison et al.
BMC neuroscience, 12, 34-34 (2011-04-22)
Mammalian taste buds contain several specialized cell types that coordinately respond to tastants and communicate with sensory nerves. While it has long been appreciated that these cells undergo continual turnover, little is known concerning how adequate numbers of cells are...
Jing Zhao et al.
American journal of physiology. Lung cellular and molecular physiology, 301(4), L547-L556 (2011-08-09)
Lysophosphatidic acid (LPA), a bioactive phospholipid, plays an important role in lung inflammation by inducing the release of chemokines and lipid mediators. Our previous studies have shown that LPA induces the secretion of interleukin-8 and prostaglandin E(2) in lung epithelial...
Claudia M Holguin et al.
Ecology and evolution, 5(14), 2929-2944 (2015-08-26)
Lance nematodes (Hoplolaimus spp.) feed on the roots of a wide range of plants, some of which are agronomic crops. Morphometric values of amphimictic lance nematode species overlap considerably, and useful morphological characters for their discrimination require high magnification and...
Lei Li et al.
Developmental cell, 15(3), 416-425 (2008-09-23)
We have identified a subcortical maternal complex (SCMC) that assembles during oocyte growth and is essential for zygotes to progress beyond the first embryonic cell divisions. At least four maternally encoded proteins contribute to this MDa complex: FLOPED, MATER, and...
Sejin Ahn et al.
PLoS biology, 6(8), e191-e191 (2008-08-08)
Although much effort has been directed at dissecting the mechanisms of central tolerance, the role of thymic stromal cells remains elusive. In order to further characterize this event, we developed a mouse model restricting LacZ to thymic stromal cotransporter (TSCOT)-expressing...
Sergio Y Alcoser et al.
BMC biotechnology, 11, 124-124 (2011-12-20)
Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of mouse and human cells. Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue. We have developed...

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