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John P Redrobe et al.
Psychopharmacology, 231(16), 3151-3167 (2014-03-01)
Here, we present the pharmacological characterisation of Lu AF64280, a novel, selective, brain penetrant phosphodiesterase (PDE) 2A inhibitor, in in vitro/in vivo assays indicative of PDE2A inhibition, and in vivo models/assays relevant to cognitive processing or antipsychotic-like activity. The in
Martin Schläpfer et al.
Critical care (London, England), 19, 45-45 (2015-04-19)
Severe sepsis is associated with approximately 50% mortality and accounts for tremendous healthcare costs. Most patients require ventilatory support and propofol is commonly used to sedate mechanically ventilated patients. Volatile anesthetics have been shown to attenuate inflammation in a variety
Wen-Yuan Wang et al.
Neuroscience letters, 541, 167-172 (2013-03-09)
N-arachidonoylethanolamine (AEA) plays a crucial neuroprotective role in certain neurodegenerative diseases. Our recent studies suggested that AEA analog N-stearoyl-l-tyrosine (NsTyr) could protect neurons from apoptosis and improve hippocampus-dependent learning and memory deficits. The present study was designed to determine the
L Zhang et al.
British journal of anaesthesia, 110 Suppl 1, i82-i91 (2013-04-23)
Isoflurane can increase pro-inflammatory cytokine interleukin (IL)-6 levels. However, the up-stream mechanism remains unknown. Nuclear factor-kappa B (NF-κB) promotes the generation of pro-inflammatory cytokines. We examined the effects of isoflurane and sevoflurane on the NF-κB signalling pathway and its association
Tobias Esper et al.
Anesthesia and analgesia, 120(1), 45-50 (2014-11-14)
The blood/gas partition coefficient of a certain volatile anesthetic is of clinical importance because it determines its velocity of uptake into and elimination from the body of a patient and thus its pharmacokinetic behavior. To date, the blood/gas partition coefficients
I Lecker et al.
British journal of anaesthesia, 110 Suppl 1, i73-i81 (2013-03-29)
Animal studies have shown that memory deficits in the early post-anaesthetic period can be prevented by pre-treatment with an inverse agonist that preferentially inhibits α5 subunit-containing γ-aminobutyric acid type A (α5GABA(A)) receptors. The goal of this in vitro study was
Stanley Leeson et al.
Anesthesia and analgesia, 119(4), 829-835 (2014-08-08)
During emergence from volatile anesthesia, hypoventilation may result from many causes. In this study, we examined the effect of hypoventilation after initial emergence from volatile anesthesia and the potential for reanesthetization. The uptake and excretion of desflurane (Des), sevoflurane, and
Christoph Kerscher et al.
Journal of cardiothoracic surgery, 9, 125-125 (2014-07-26)
Macroscopic cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion (HITHOC) is a new multimodal approach for selected patients with primary and secondary pleural tumors, which may provide the patient with better local tumor control and increased overall survival rate. We present
E G Agavelyan et al.
Anesteziologiia i reanimatologiia, (1)(1), 14-17 (2013-07-03)
Myorelaxants use decrease trend appeared since the end of 80 years of the 20th century. The trend is connected with use of the new narcotic analgesics (Remifentanil), intravenous (Propofol) and inhalation (Sevoflurane) anaesthetics. These drugs are manageable and predictable, they
G Kunst et al.
Anaesthesia, 70(4), 467-482 (2015-03-13)
Preconditioning has been shown to reduce myocardial damage caused by ischaemia-reperfusion injury peri-operatively. Volatile anaesthetic agents have the potential to provide myocardial protection by anaesthetic preconditioning and, in addition, they also mediate renal and cerebral protection. A number of proof-of-concept
Ross C Terrell
Anesthesiology, 108(3), 531-533 (2008-02-23)
Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in
Eun Jung Cho et al.
Anesthesiology, 120(6), 1354-1361 (2014-02-26)
Midazolam has been widely studied for preventing emergence agitation. The authors previously reported that in children with sevoflurane anesthesia, intravenous administration of midazolam (0.05 mg/kg) before the end of surgery reduced the incidence of emergence agitation but prolonged the emergence
Jelka Masin-Spasovska et al.
Current drug safety, 8(2), 141-144 (2013-07-13)
A liver dysfunction induced by halogenated volatile anaesthetics is considered as a significant diagnostic problem. The aim of our report was to describe the first case of lethal hepatic failure in a female patient undergoing kidney transplantation (KTx) from a
G Kumar et al.
Anaesthesia, 69(10), 1138-1150 (2014-05-23)
With the popularity of ambulatory surgery ever increasing, we carried out a systematic review and meta-analysis to determine whether the type of anaesthesia used had any bearing on patient outcomes. Total intravenous propofol anaesthesia was compared with two of the
H Fukagawa et al.
British journal of anaesthesia, 113(6), 1032-1038 (2014-08-05)
Our previous reports demonstrated that genetic deletion of μ-opioid receptor has no influence on the anaesthetic and antinociceptive effects of nitrous oxide (N2O) in mice, and that an antagonist selective for κ-opioid receptor (KOP), but not that selective for δ-opioid
Matthias Kreuzer et al.
Anesthesia and analgesia, 118(1), 183-191 (2013-12-21)
Monitoring and automated online analysis of brain electrical activity are frequently used for verifying brain diseases and for estimating anesthetic depth in subjects undergoing surgery. However, false diagnosis with potentially catastrophic consequences for patients such as intraoperative awareness may result
Eileen M Sakai et al.
Pharmacotherapy, 25(12), 1773-1788 (2005-11-25)
Clinical pharmacists rarely are involved in the selection and dosing of anesthetic agents. However, when practicing evidence-based medicine in a cost-conscious health care system, optimizing drug therapy is imperative in all areas. Thus, we provide general information on anesthesiology, including
Nicolas Cottron et al.
Anesthesia and analgesia, 119(1), 67-75 (2014-05-09)
Preoperative flushing of an anesthesia workstation is an alternative for preparation of the anesthesia workstation before use in malignant hyperthermia-susceptible patients (MHS). We studied in vitro, using a test lung, the washout profile of sevoflurane in 7 recent workstations during
Maria I Lioudyno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(41), 16310-16322 (2013-10-11)
The molecular targets and neural circuits that underlie general anesthesia are not fully elucidated. Here, we directly demonstrate that Kv1-family (Shaker-related) delayed rectifier K(+) channels in the central medial thalamic nucleus (CMT) are important targets for volatile anesthetics. The modulation
E E Lindholm et al.
Anaesthesia, 69(6), 558-572 (2014-04-12)
The aim of this study was to define pre-operative echocardiographic data and explore if postoperative indices of cardiac function after open abdominal aortic surgery were affected by the anaesthetic regimen. We hypothesised that volatile anaesthesia would improve indices of cardiac
Deepak Gupta et al.
Middle East journal of anaesthesiology, 21(6), 863-867 (2013-05-03)
The concerns for hyperoxia-related brain tissue injury are well known to the medical community. The cerebro-vasodilatory properties of sevoflurane may create relative cerebral tissue "hyperoxia" during inhalational induction as compared to a propofol-based intravenous induction of anesthesia. The objective for
Koichi Yuki et al.
Anesthesia and analgesia, 117(4), 803-811 (2013-08-21)
We previously demonstrated that propofol interacted with the leukocyte adhesion molecule leukocyte function-associated antigen-1 (LFA-1) and inhibited the production of interleukin-2 via LFA-1 in a dependent manner. However, the binding site(s) of propofol on LFA-1 remains unknown. First, the inhibition
Sebastian Hafner et al.
Shock (Augusta, Ga.), 43(2), 140-147 (2014-12-20)
Blunt chest trauma causes pulmonary and systemic inflammation. It is still a matter of debate whether the long-term course of this inflammatory response is associated with persistent impairment of lung function. We hypothesized that an increase of inflammatory biomarkers may
Ole K Møller-Helgestad et al.
International journal of cardiology, 178, 153-158 (2014-12-03)
Cardiogenic shock as a complication to an acute myocardial infarction has an unacceptably high death rate that has not changed for the last 15years. Mortality is partly related to organ hypoperfusion and mechanical assist devices are used for the most
T M Ramage et al.
British journal of anaesthesia, 110 Suppl 1, i39-i46 (2013-04-18)
Many anaesthetics when given to young animals cause cell death and learning deficits that persist until much later in life. Recent attempts to compare the relative safety or toxicity between different agents have not adequately controlled for the relative dose
Max T Baker
Anesthesia and analgesia, 104(6), 1447-1451 (2007-05-22)
Sevoflurane is currently available in the United States from two manufacturers: Ultane (Abbott Laboratories, Inc.) and a generic product, Sevoflurane Inhalation Anesthetic (Baxter Healthcare Corp.). These products are rated therapeutically equivalent by the Food and Drug Administration, but there are
Irene Cuadrado-Berrocal et al.
Biochemical pharmacology, 93(4), 428-439 (2015-01-06)
Therapeutic approaches to protect the heart from ischemia/reperfusion (I/R) injury are an area of intense research, as myocardial infarction is a major cause of mortality and morbidity. Diterpenes are bioactive natural products with great therapeutic potential. In the present study
Qingxiu Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(7), 1183-1189 (2014-06-08)
Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment. 2-deoxy-d-glucose (2-DG) is a synthetic analogue of glucose and is clinically used in medical imaging safely. We examined the effect of 2-DG on sevoflurane-induced
V V Shmelev et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(4), 30-34 (2013-06-07)
It was studied 238 patients after the reconstructive surgeries of atherosclerotic stenosing lesions of carotid arteries using different types of anesthesia. Neuropsychological testing included MMSE, the Frontal Assessment battery and the Clock drawing test. Regional anesthesia in the combination with
Maliwan Oofuvong et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(11), 1470-1475 (2014-01-17)
To compare the incidence and severity of emergence agitation, recovery profile, and adverse events between desflurane and sevoflurane anesthesia in unpremedicated pediatric ambulatory urologic surgery patients. The study was conducted among 136 healthy children, aged six months to nine years
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