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Deepak Gupta et al.
Middle East journal of anaesthesiology, 21(6), 863-867 (2013-05-03)
The concerns for hyperoxia-related brain tissue injury are well known to the medical community. The cerebro-vasodilatory properties of sevoflurane may create relative cerebral tissue "hyperoxia" during inhalational induction as compared to a propofol-based intravenous induction of anesthesia. The objective for
Maria I Lioudyno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(41), 16310-16322 (2013-10-11)
The molecular targets and neural circuits that underlie general anesthesia are not fully elucidated. Here, we directly demonstrate that Kv1-family (Shaker-related) delayed rectifier K(+) channels in the central medial thalamic nucleus (CMT) are important targets for volatile anesthetics. The modulation
Nicolas Cottron et al.
Anesthesia and analgesia, 119(1), 67-75 (2014-05-09)
Preoperative flushing of an anesthesia workstation is an alternative for preparation of the anesthesia workstation before use in malignant hyperthermia-susceptible patients (MHS). We studied in vitro, using a test lung, the washout profile of sevoflurane in 7 recent workstations during
Eileen M Sakai et al.
Pharmacotherapy, 25(12), 1773-1788 (2005-11-25)
Clinical pharmacists rarely are involved in the selection and dosing of anesthetic agents. However, when practicing evidence-based medicine in a cost-conscious health care system, optimizing drug therapy is imperative in all areas. Thus, we provide general information on anesthesiology, including
G Kunst et al.
Anaesthesia, 70(4), 467-482 (2015-03-13)
Preconditioning has been shown to reduce myocardial damage caused by ischaemia-reperfusion injury peri-operatively. Volatile anaesthetic agents have the potential to provide myocardial protection by anaesthetic preconditioning and, in addition, they also mediate renal and cerebral protection. A number of proof-of-concept
Christoph Kerscher et al.
Journal of cardiothoracic surgery, 9, 125-125 (2014-07-26)
Macroscopic cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion (HITHOC) is a new multimodal approach for selected patients with primary and secondary pleural tumors, which may provide the patient with better local tumor control and increased overall survival rate. We present
Sebastian Hafner et al.
Shock (Augusta, Ga.), 43(2), 140-147 (2014-12-20)
Blunt chest trauma causes pulmonary and systemic inflammation. It is still a matter of debate whether the long-term course of this inflammatory response is associated with persistent impairment of lung function. We hypothesized that an increase of inflammatory biomarkers may
E E Lindholm et al.
Anaesthesia, 69(6), 558-572 (2014-04-12)
The aim of this study was to define pre-operative echocardiographic data and explore if postoperative indices of cardiac function after open abdominal aortic surgery were affected by the anaesthetic regimen. We hypothesised that volatile anaesthesia would improve indices of cardiac
Koichi Yuki et al.
Anesthesia and analgesia, 117(4), 803-811 (2013-08-21)
We previously demonstrated that propofol interacted with the leukocyte adhesion molecule leukocyte function-associated antigen-1 (LFA-1) and inhibited the production of interleukin-2 via LFA-1 in a dependent manner. However, the binding site(s) of propofol on LFA-1 remains unknown. First, the inhibition
Ross C Terrell
Anesthesiology, 108(3), 531-533 (2008-02-23)
Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in
L Zhang et al.
British journal of anaesthesia, 110 Suppl 1, i82-i91 (2013-04-23)
Isoflurane can increase pro-inflammatory cytokine interleukin (IL)-6 levels. However, the up-stream mechanism remains unknown. Nuclear factor-kappa B (NF-κB) promotes the generation of pro-inflammatory cytokines. We examined the effects of isoflurane and sevoflurane on the NF-κB signalling pathway and its association
G Kumar et al.
Anaesthesia, 69(10), 1138-1150 (2014-05-23)
With the popularity of ambulatory surgery ever increasing, we carried out a systematic review and meta-analysis to determine whether the type of anaesthesia used had any bearing on patient outcomes. Total intravenous propofol anaesthesia was compared with two of the
Tatsushi Mutoh et al.
Life sciences, 92(14-16), 821-828 (2013-03-19)
Volatile anesthetics have distinct odors and some are irritating to the upper airway and may cause cough and laryngospasm, which may result, in part, from stimulation of C-fiber reflex. Local exposure of such anesthetics increases the sensitivity of capsaicin-sensitive laryngeal
I Lecker et al.
British journal of anaesthesia, 110 Suppl 1, i73-i81 (2013-03-29)
Animal studies have shown that memory deficits in the early post-anaesthetic period can be prevented by pre-treatment with an inverse agonist that preferentially inhibits α5 subunit-containing γ-aminobutyric acid type A (α5GABA(A)) receptors. The goal of this in vitro study was
Tobias Esper et al.
Anesthesia and analgesia, 120(1), 45-50 (2014-11-14)
The blood/gas partition coefficient of a certain volatile anesthetic is of clinical importance because it determines its velocity of uptake into and elimination from the body of a patient and thus its pharmacokinetic behavior. To date, the blood/gas partition coefficients
Eun Jung Cho et al.
Anesthesiology, 120(6), 1354-1361 (2014-02-26)
Midazolam has been widely studied for preventing emergence agitation. The authors previously reported that in children with sevoflurane anesthesia, intravenous administration of midazolam (0.05 mg/kg) before the end of surgery reduced the incidence of emergence agitation but prolonged the emergence
Jelka Masin-Spasovska et al.
Current drug safety, 8(2), 141-144 (2013-07-13)
A liver dysfunction induced by halogenated volatile anaesthetics is considered as a significant diagnostic problem. The aim of our report was to describe the first case of lethal hepatic failure in a female patient undergoing kidney transplantation (KTx) from a
H Fukagawa et al.
British journal of anaesthesia, 113(6), 1032-1038 (2014-08-05)
Our previous reports demonstrated that genetic deletion of μ-opioid receptor has no influence on the anaesthetic and antinociceptive effects of nitrous oxide (N2O) in mice, and that an antagonist selective for κ-opioid receptor (KOP), but not that selective for δ-opioid
Matthias Kreuzer et al.
Anesthesia and analgesia, 118(1), 183-191 (2013-12-21)
Monitoring and automated online analysis of brain electrical activity are frequently used for verifying brain diseases and for estimating anesthetic depth in subjects undergoing surgery. However, false diagnosis with potentially catastrophic consequences for patients such as intraoperative awareness may result
E G Agavelyan et al.
Anesteziologiia i reanimatologiia, (1)(1), 14-17 (2013-07-03)
Myorelaxants use decrease trend appeared since the end of 80 years of the 20th century. The trend is connected with use of the new narcotic analgesics (Remifentanil), intravenous (Propofol) and inhalation (Sevoflurane) anaesthetics. These drugs are manageable and predictable, they
T M Ramage et al.
British journal of anaesthesia, 110 Suppl 1, i39-i46 (2013-04-18)
Many anaesthetics when given to young animals cause cell death and learning deficits that persist until much later in life. Recent attempts to compare the relative safety or toxicity between different agents have not adequately controlled for the relative dose
John P Redrobe et al.
Psychopharmacology, 231(16), 3151-3167 (2014-03-01)
Here, we present the pharmacological characterisation of Lu AF64280, a novel, selective, brain penetrant phosphodiesterase (PDE) 2A inhibitor, in in vitro/in vivo assays indicative of PDE2A inhibition, and in vivo models/assays relevant to cognitive processing or antipsychotic-like activity. The in
Qingxiu Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(7), 1183-1189 (2014-06-08)
Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment. 2-deoxy-d-glucose (2-DG) is a synthetic analogue of glucose and is clinically used in medical imaging safely. We examined the effect of 2-DG on sevoflurane-induced
Maliwan Oofuvong et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(11), 1470-1475 (2014-01-17)
To compare the incidence and severity of emergence agitation, recovery profile, and adverse events between desflurane and sevoflurane anesthesia in unpremedicated pediatric ambulatory urologic surgery patients. The study was conducted among 136 healthy children, aged six months to nine years
V V Shmelev et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(4), 30-34 (2013-06-07)
It was studied 238 patients after the reconstructive surgeries of atherosclerotic stenosing lesions of carotid arteries using different types of anesthesia. Neuropsychological testing included MMSE, the Frontal Assessment battery and the Clock drawing test. Regional anesthesia in the combination with
L He et al.
Anaesthesia and intensive care, 41(3), 328-333 (2013-05-11)
We investigated the effects of dexmedetomidine infusion on the end-tidal concentration of sevoflurane required for smooth removal of the laryngeal mask airway (LMA) and on the incidence of respiratory complications during postoperative recovery in paediatric patients anaesthetised with sevoflurane. Eighty-seven
R Nitzschke et al.
British journal of anaesthesia, 110(6), 957-965 (2013-03-07)
It is unclear what factors affect the uptake of sevoflurane administered through the membrane oxygenator during cardiopulmonary bypass (CPB) and whether this can be monitored via the oxygenator exhaust gas. Stable delivery of sevoflurane was administered to 30 elective cardiac
[Sevoflurane and propofol: original and generic].
B Al-Nasser
Annales francaises d'anesthesie et de reanimation, 27(1), 120-122 (2008-01-15)
Fabiola Fernández-Silva et al.
Medical mycology, 52(1), 29-35 (2014-03-01)
Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated
Stanley Leeson et al.
Anesthesia and analgesia, 119(4), 829-835 (2014-08-08)
During emergence from volatile anesthesia, hypoventilation may result from many causes. In this study, we examined the effect of hypoventilation after initial emergence from volatile anesthesia and the potential for reanesthetization. The uptake and excretion of desflurane (Des), sevoflurane, and
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