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Amanda Selk et al.
Obstetrics and gynecology, 118(4), 941-949 (2011-09-22)
To estimate the benefits and harms of misoprostol use for cervical dilation in patients undergoing operative hysteroscopy. We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (from inception to February 2011). We also searched trial registries, other...
M Sirakov
Akusherstvo i ginekologiia, 51(3), 50-54 (2012-12-15)
The article is dedicated on the medicinal product known under the INN Misoprostol, a prostaglandin E1 analogue that is world wide "off label" used in obstetrics and gynecology. Contemporary publications are provided to prove the effects of the medicinal product...
[Misoprostol off label essential for women's health].
Kristina Gemzell Danielsson
Lakartidningen, 110(46), 2045-2046 (2014-01-02)
Reviewer's commentary on 'Continuation of pregnancy after first-trimester exposure to mifepristone: an observational prospective study'.
S Cameron
BJOG : an international journal of obstetrics and gynaecology, 120(5), 575-575 (2013-04-20)
Karen J Gibbins et al.
American journal of obstetrics and gynecology, 208(3), 181-183 (2012-08-21)
We reviewed the literature to determine the optimal medical treatment of postpartum hemorrhage caused by uterine atony. Of the available uterotonics, only misoprostol and oxytocin have undergone rigorous comparative study. Of the 2, misoprostol is inferior: 2 recent well-done randomized...
Olufemi T Oladapo et al.
The Cochrane database of systematic reviews, 2(2), CD009336-CD009336 (2012-02-18)
Advance community distribution of misoprostol for preventing or treating postpartum haemorrhage (PPH) has become an attractive strategy to expand uterotonic coverage to places where conventional uterotonic use is not feasible. However, the value and safety of this strategy remain contentious....
Amrita Ahluwalia et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(6), G602-G610 (2014-07-26)
Clinical studies indicate that prostaglandins of E class (PGEs) may promote healing of tissue injury e.g., gastroduodenal and dermal ulcers. However, the precise roles of PGEs, their E-prostanoid (EP) receptors, signaling pathways including cAMP and cAMP response element-binding protein (CREB)...
Mette Løkeland et al.
Acta obstetricia et gynecologica Scandinavica, 93(7), 647-653 (2014-04-29)
To evaluate the acceptability and efficacy of medical abortion at home up to 63 days' gestation without limits on travel distance to a registered institution. Observational prospective study. Haukeland University Hospital between May 2006 and May 2009. A total of 1018...
Mohammad Reza Fazel et al.
Middle East journal of anaesthesiology, 22(1), 41-46 (2013-07-10)
Post partum bleeding is a major cause of mortality and morbidity in pregnant women. In this study the effects of rectal misoprostol and oxytocin on post-cesarean bleeding are compared. In this clinical trial 100 pregnant women candidate of elective cesarean...
A A Adeniyi et al.
Nigerian journal of clinical practice, 17(3), 287-291 (2014-04-10)
To compare the effectiveness of two dosing regimens of vaginal misoprostol for cervical ripening and induction of labour. Pregnant women with singleton low risk pregnancy at term scheduled for elective induction of labour were randomized to receive either 25 μg...
Zeba Sathar et al.
Issues in brief (Alan Guttmacher Institute), (4)(4), 1-8 (2013-09-07)
The current law in Pakistan permits abortion only under narrow circumstances. As a result, women resort to clandestine and unsafe abortion procedures, which often lead to complications. This report summarizes findings from a study that examined the conditions under which...
Corina Schoen et al.
Obstetrics and gynecology, 124(2 Pt 2 Suppl 1), 466-468 (2014-07-09)
Misoprostol is a commonly used agent for induction of labor. Anaphylactic reactions are infrequent but possible complications of drugs administered to the pregnant patient. Although antibiotics, latex, and anesthetic agents are more common triggers for anaphylaxis, induction agents are also...
Wendy R Sheldon et al.
Expert opinion on investigational drugs, 21(2), 235-250 (2012-01-12)
Uterotonic drugs are recommended for the prevention and treatment of postpartum hemorrhage (PPH), and oxytocin is considered the gold standard for both indications due to its established efficacy and safety. Unfortunately, access to oxytocin is still limited in many low-resource...
S Kehl et al.
BJOG : an international journal of obstetrics and gynaecology, 122(1), 129-136 (2014-10-21)
To evaluate the efficacy of inducing labour using a double-balloon catheter and oral misoprostol sequentially, in comparison with oral misoprostol alone. A multicentre randomised controlled trial. Five hospitals in Germany. A total of 326 pregnant women with an unfavourable cervix...
Marta Jozwiak et al.
The Cochrane database of systematic reviews, 3(3), CD009792-CD009792 (2013-04-02)
Induction of labour is a common obstetric intervention, with between 20% and 30% of births reported to occur following induction of labour. Women with a prior caesarean delivery have an increased risk of uterine rupture, particularly when labour is induced....
Clara Ladi Ejembi et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 122(3), 187-189 (2013-06-26)
New global guidance has emerged to support countries as they consider introducing or scaling-up misoprostol for postpartum hemorrhage (PPH). The World Health Organization (WHO) and the International Federation of Gynecology and Obstetrics (FIGO) recognize the critical role that community and...
Joshua P Vogel et al.
The Cochrane database of systematic reviews, 9(9), CD010648-CD010648 (2013-09-24)
Labour dystocia is associated with a number of adverse maternal and neonatal outcomes. Augmentation of labour is a commonly used intervention in cases of labour dystocia. Misoprostol is an inexpensive and stable prostaglandin E1 analogue that can be administered orally...
New anomalies due to methotrexate and misoprostol exposure in early pregnancy.
Kate MacDonald et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 122(3), 267-268 (2013-06-25)
Wendy R Sheldon et al.
BMC pregnancy and childbirth, 13, 46-46 (2013-02-26)
Active management of the third stage of labor is recommended for the prevention of post-partum hemorrhage and commonly entails prophylactic administration of a uterotonic agent, controlled cord traction, and uterine massage. While oxytocin is the first-choice uterotonic, it is not...
Onur Erol et al.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 35(10), 914-916 (2013-10-30)
Triploidy is a highly lethal condition, and is thus very rarely observed in live births. It may result in significant medical risk to the pregnant woman. A 32-year-old multigravid woman presented for prenatal care. Ultrasound examination at 14+3 weeks of...
María Fernanda Cavieres
Revista medica de Chile, 139(4), 516-523 (2011-09-01)
Misoprostol, a synthetic analog of prostaglandin E1, is currently used in Chile and other countries as an antiulcer medication, mainly for the prevention of non-steroidal anti-inflammatory-induced gastric ulcers. Due to its uterotonic properties, it is also indicated in obstetrics for...
Jeffrey Michael Smith et al.
BMC pregnancy and childbirth, 13, 44-44 (2013-02-21)
Hemorrhage continues to be a leading cause of maternal death in developing countries. The 2012 World Health Organization guidelines for the prevention and management of postpartum hemorrhage (PPH) recommend oral administration of misoprostol by community health workers (CHWs). However, there...
Heleen J van Beekhuizen et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 122(3), 234-237 (2013-06-25)
To evaluate the efficacy and safety of misoprostol among patients with retained placenta in a low-resource setting. A prospective, multicenter, randomized, double-blind, placebo-controlled trial was carried out in Tanzania between April 2008 and November 2011. It included patients who delivered...
C W Ho et al.
Alimentary pharmacology & therapeutics, 37(8), 819-824 (2013-02-26)
Poor adherence to gastroprotective agents (GPAs) is common among users of nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (ASA). There are little data on the utilization of GPAs among NSAID and ASA users complicated by ulcer bleeding. To study the...
Picklu Chaudhuri et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 128(1), 48-52 (2014-10-04)
To evaluate whether a combination of misoprostol and oxytocin more effectively reduces blood loss during and after cesarean delivery than does oxytocin alone among women with known risk factors for postpartum hemorrhage (PPH). A prospective, randomized, double-blind, placebo-controlled trial was...
Reply: To PMID 23659988.
Methodius G Tuuli et al.
American journal of obstetrics and gynecology, 210(1), 91-92 (2013-08-27)
Hiroshi Satoh et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 227-235 (2013-11-21)
Antisecretory drugs such as histamine H₂-receptor antagonists and proton pump inhibitors are commonly used for the treatment of upper gastrointestinal mucosal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). However, it has recently been reported that these drugs exacerbate NSAID-induced small...
Deborah Bartz et al.
Obstetrics and gynecology, 122(1), 57-63 (2013-06-08)
To compare the efficacy and acceptability of buccal misoprostol or a synthetic osmotic cervical dilator for cervical preparation before same-day late first-trimester and early second-trimester surgical abortion. In this randomized, double-blind trial, we compared 400 micrograms of buccal misoprostol with...
Agustín Conde-Agudelo et al.
American journal of obstetrics and gynecology, 209(1), 40-40 (2013-03-20)
To evaluate the efficacy and safety of prophylactic misoprostol use at cesarean delivery for reducing intraoperative and postoperative hemorrhage. Systematic review and metaanalysis of randomized controlled trials. Seventeen studies (3174 women) were included of which 7 evaluated misoprostol vs oxytocin...
G Justus Hofmeyr et al.
The Cochrane database of systematic reviews, 7(7), CD008982-CD008982 (2013-07-17)
The primary objective of postpartum haemorrhage (PPH) prevention and treatment is to reduce maternal deaths. Misoprostol has the major public health advantage over injectable medication that it can more easily be distributed at community level. Because misoprostol might have adverse...
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