Showing 1-30 of 86 results for "


Cristina Miró-Julià et al.
Journal of immunology (Baltimore, Md. : 1950), 186(4), 2344-2354 (2011-01-11)
The scavenger receptor cysteine-rich superfamily (SRCR-SF) members are transmembrane and/or secreted receptors exhibiting one or several repeats of a cysteine-rich protein module of ∼100 aa, named scavenger receptor cysteine-rich (SRCR). Two types of SRCR domains (A or B) have been...
Igor A Schepetkin et al.
Journal of immunology (Baltimore, Md. : 1950), 183(10), 6754-6766 (2009-10-23)
Epilobium angustifolium has been traditionally used to treat of a number of diseases; however, not much is known regarding its effect on innate immune cells. In this study, we report that extracts of E. angustifolium activated functional responses in neutrophils...
John C Gensel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9966-9976 (2015-07-15)
Spinal cord injury (SCI) activates macrophages, endowing them with both reparative and pathological functions. The mechanisms responsible for these divergent functions are unknown but are likely controlled through stochastic activation of different macrophage receptor subtypes. Various danger-associated molecular patterns released...
Ghewa A El-Achkar et al.
PloS one, 14(5), e0216405-e0216405 (2019-05-10)
Statins exert pleiotropic and beneficial anti-inflammatory and antioxidant effects. We have previously reported that macrophages treated with statins increased the expression of heme oxygenase-1 (HO-1), an inducible anti-inflammatory and cytoprotective stress protein, responsible for the degradation of heme. In the...
Zongbin Song et al.
Scientific reports, 7(1), 10350-10350 (2017-09-06)
Obesity is associated with increased risk for chronic pain. Basic mechanisms for this association are poorly understood. Using a milder version of a radicular pain model, local inflammation of the dorsal root ganglion (DRG), we observed marked increases in mechanical...
Thomas Boehm et al.
International journal of immunopathology and pharmacology, 34, 2058738420954945-2058738420954945 (2020-10-01)
During human diamine oxidase (DAO) ELISA development we noticed that in serum DAO concentrations appear to be higher when compared to plasma. Neutrophils contain DAO in the specific granules and we hypothesized that DAO is released from neutrophils during serum...
Takashi Matsuo et al.
Journal of immunology (Baltimore, Md. : 1950), 202(11), 3161-3172 (2019-04-26)
A defect in TCR-proximal signaling is a major characteristic of CD4 T cells in systemic lupus erythematosus; however, it is not fully known how defects in TCR signaling lead to lupus-like systemic autoimmunity characterized by germinal center development and autoantibody...
Stephanie Saul et al.
Journal of leukocyte biology, 106(5), 1101-1115 (2019-06-20)
Neutrophils play a central role in immunity and inflammation via their intrinsic ability to migrate into inflamed tissue, to phagocytose pathogens, and to kill bacterial and fungi by releasing large quantities of superoxide anions and lytic enzymes. The molecular pathways...
Marta Librán-Pérez et al.
Fish & shellfish immunology, 82, 173-182 (2018-08-07)
The innate immune response is able to ward off pathogens and remember previous infections using different mechanisms; this kind of immune reaction has been called "trained immunity". Changes in cellular metabolism (aerobic glycolysis) have been observed during training with some...
Huixing Wu et al.
The Journal of biological chemistry, 286(17), 14932-14940 (2011-02-24)
Keratinocyte growth factor (KGF) is an epithelial mitogen that has been reported to protect the lungs from a variety of insults. In this study, we tested the hypothesis that KGF augments pulmonary host defense. We found that a single dose...
David Frank et al.
mBio, 9(4) (2018-07-19)
Mice lacking expression of the homologous phosphatases Sts-1 and Sts-2 (Sts-/- mice) are resistant to disseminated candidiasis caused by the fungal pathogen Candida albicans To better understand the immunological mechanisms underlying the enhanced resistance of Sts-/- mice, we examined the...
Shui-Bing Liu et al.
Journal of neurochemistry, 153(2), 252-263 (2019-10-31)
Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral...
Geelsu Hwang et al.
PLoS pathogens, 13(6), e1006407-e1006407 (2017-06-16)
Candida albicans is frequently detected with heavy infection by Streptococcus mutans in plaque-biofilms from children with early-childhood caries (ECC). This cross-kingdom biofilm contains an extensive matrix of extracellular α-glucans that is produced by an exoenzyme (GtfB) secreted by S. mutans....
Nan Zhang et al.
The Journal of experimental medicine, 216(6), 1291-1300 (2019-05-03)
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in...
Junyu Chen et al.
Science advances, 7(6) (2021-02-05)
Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans...
Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells
Sun Y, et al.
Cell Stress & Chaperones, 23(5), 1069-1078 (2018)
N Kareem et al.
Fish & shellfish immunology, 74, 213-222 (2018-01-01)
The rapid emergence of drug resistance, unfavourable immunosuppression and mounting evidence to suggest the deleterious accumulation of drug breakdown residues within animal tissues has driven a strong desire to move away from these current methods of disease control. Some natural...
Daniel B Lyle et al.
Journal of biomedical materials research. Part A, 92(1), 205-213 (2009-01-28)
Complement plays an important role in the immune attack against invading microorganisms. However, blood-contacting medical device biomaterials lacking specific complement inhibitors, with free hydroxyl and/or amino groups, or with absorbed antibodies, may inappropriately activate complement. Inappropriate activation by either the...
Qiao Zhong et al.
Journal of immunology (Baltimore, Md. : 1950), 200(12), 3913-3925 (2018-05-02)
Prevalence of circulating immunocomplexes (ICs) strongly correlates with rheumatoid arthritis (RA) in humans. Deposits of IgG-ICs are abundant in affected joints of patients, yet molecular mechanisms for the pathogenic roles of such ICs are not fully understood. In this study...
Sílvia Vieira et al.
Acta biomaterialia, 93, 74-85 (2019-02-02)
In this study, methacrylated gellan-gum (GG-MA) heteropolysaccharide is proposed as a hydrogel for drug delivery and bone tissue engineering applications. Calcium-enriched beads obtained from the crosslinking of 1% (w/v) GG-MA solutions with 0.1 MCaCl2 were investigated, considering their intrinsic capacity to...
T X Cui et al.
The American journal of physiology, 275(6 Pt 1), G1361-G1366 (1998-12-09)
To study the role of Kupffer cells in the aggravation of liver injury, effects of zymosan on acute liver damage were explored using perfused livers of rats 24 h after intraperitoneal injection of D-galactosamine (800 mg/kg). The leakage of lactate...
Carlos Angulo et al.
Immunobiology, 224(1), 102-109 (2018-12-01)
C-type lectins are a principal carbohydrate recognition mechanism as glucans on cell surfaces. This study identified and investigated molecular characterization and immune roles of a novel c-type lectin 17A from Totoaba macdonaldi (TmCLEC17A), which were described in head-kidney leukocytes after...
Lene Halkjær et al.
Frontiers in immunology, 11, 774-774 (2020-05-21)
We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human plasma samples. In order to capture the activation products iC3b and C3dg in a specific and...
Lin Luo et al.
Journal of leukocyte biology, 107(2), 251-262 (2019-08-31)
In innate immune cells, pathogens and danger signals activate TLRs, unleashing potent and tailored inflammatory responses. Previously, we reported that an immune-specific transmembrane adaptor, SLP adaptor and CSK interacting membrane protein (SCIMP), interacts with TLR4 via direct binding to its...
Anne Troldborg et al.
Journal of immunological methods, 486, 112866-112866 (2020-09-18)
In human autoimmune diseases, low plasma levels of complement factors C3 and C4 are commonly used as a proxy for complement activation. The measurements of C3 and C4 concentrations (the result of synthesis and consumption) however, show low sensitivity in...
Tomás Cárdenas-Reyna et al.
Developmental and comparative immunology, 77, 350-358 (2017-09-11)
This study attempts to describe the immunostimulatory effects of three fungal glucans on innate immunity responses in an in vitro assays using Pacific red snapper leukocytes. First, the yield glucans obtained was higher in Aspergillus niger, follow by Aspergillus ochraceus and...
Hassan Javanbakht et al.
Molecular therapy. Nucleic acids, 11, 441-454 (2018-06-03)
Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface antigen (HBsAg) loss following treatment. The goal for next generation CHB...
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue
Kern K, et al.
Frontiers in Immunology, 9, 2261-2261 (2018)
Charlotte D C C van der Heijden et al.
Cardiovascular research, 116(2), 317-328 (2019-05-24)
Supranormal levels of aldosterone are associated with an increased cardiovascular risk in humans, and with accelerated atherosclerosis in animal models. Atherosclerosis is a low-grade inflammatory disorder, with monocyte-derived macrophages as major drivers of plaque formation. Monocytes can adopt a long-term...