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Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays.

Food research international (Ottawa, Ont.) (2018-03-28)
M Figueiredo-González, P Reboredo-Rodríguez, C González-Barreiro, J Simal-Gándara, P Valentão, A Carrasco-Pancorbo, P B Andrade, B Cancho-Grande
ABSTRACT

In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (α-glucosidase and α-amylase). 'Cornicabra' displayed the best inhibitory activity against all enzymes, when compared to 'Picual': BuChE (IC50 = 156 ± 4 and 308 ± 33 mg mL-1), LOX (IC50 = 26 ± 0.5 and 37 ± 3 mg mL-1), hMAO-A (IC50 = 20 ± 2 and 37 ± 0.2 mg mL-1), hMAO-B (IC50 = 131 ± 7 and 215 ± 13 mg mL-1) and α-glucosidase (IC50 = 154 ± 17 and 251 ± 31 mg mL-1), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in 'Cornicabra' EVOO.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Propylamine hydrochloride, ≥99%
Sigma-Aldrich
Kynuramine dihydrobromide, crystalline