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  • Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics.

Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics.

Frontiers in neuroscience (2018-10-05)
Laura Ferlauto, Antonio Nunzio D'Angelo, Paola Vagni, Marta Jole Ildelfonsa Airaghi Leccardi, Flavio Maurizio Mor, Estelle Annick Cuttaz, Marc Olivier Heuschkel, Luc Stoppini, Diego Ghezzi
ABSTRACT

Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectrum of possibilities to tackle this issue. Nevertheless, despite the advancements in this field, further improvements in the fabrication of conductive hydrogel-based electrodes are still required. In this work, we report the fabrication of a conductive hydrogel-based microelectrode array for neural recording using a hybrid material composed of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate), and alginate. The mechanical properties of the conductive hydrogel have been investigated using imaging techniques, while the electrode arrays have been electrochemically characterized at each fabrication step, and successfully validated both in vitro and in vivo. The presence of the conductive hydrogel, selectively electrodeposited onto the platinum microelectrodes, allowed achieving superior electrochemical characteristics, leading to a lower electrical noise during recordings. These findings represent an advancement in the design of soft conductive electrodes for neuroprosthetic applications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3,4-Ethylenedioxythiophene, 97%
Sigma-Aldrich
Poly(ethylene glycol) dimethacrylate, average Mn 550, contains 80-120 ppm MEHQ as inhibitor, 270-330 ppm BHT as inhibitor
Sigma-Aldrich
Poly(4-styrenesulfonic acid) solution, Mw ~75,000, 18 wt. % in H2O
Sigma-Aldrich
Alginic acid sodium salt from brown algae, Medium viscosity
Sigma-Aldrich
Calcium carbonate, BioReagent, suitable for insect cell culture, ≥99.0%