5-Methyl-2-thienylcalcium iodide.

Dalton transactions (Cambridge, England : 2003) (2018-05-05)
Alexander Koch, Sven Krieck, Helmar Görls, Matthias Westerhausen
ABSTRACT

The reduction of 2-bromo- and 3-bromothiophene with calcium powder gives impure thienylcalcium complexes due to interference of various subsequent metalation and calcium-halogen exchange reactions as well as ether degradation. Therefore, calcium-iodine exchange succeeds via the reaction of trimethylsilylmethylcalcium halide with 3-iodothiophene in tetrahydrofuran at -78 °C in the presence of chloro-trimethylsilane, leading to the quantitative formation of 3-(trimethylsilyl)thiophene. The synthesis and isolation of a thienylcalcium halide, a heavy Grignard reagent with a thienyl group, is possible via the reduction of 2-iodo-5-methylthiophene with activated calcium in THF. Substitution of the thf ligands in 5-methyl-2-thienylcalcium iodide ([5-MeThien-2-Ca(thf)4I], 1) by dissolution in tetrahydropyran (THP) leads to the thp complex of 5-methyl-2-thienylcalcium iodide ([5-MeThien-2-Ca(thp)4I], 2). A low field shift of the calcium-bound carbon atom is characteristic of thienylcalcium complexes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Iodo-5-methylthiophene, 97%
Sigma-Aldrich
3-Iodothiophene, ≥97%