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  • Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.

Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.

Angewandte Chemie (International ed. in English) (2009-05-09)
Zhaohua Huang, Mahmoud Reza Jaafari, Francis C Szoka
ABSTRACT

Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1) are valuable new components for liposome formulation.