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Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.

Cancer letters (2019-01-24)
Zhishan Xu, Yujiao Zhang, Shumiao Zhang, Xianglei Jia, Genshen Zhong, Yuliang Yang, Qing Du, Juanjuan Li, Zhe Liu
ABSTRACT

Herein we present half-sandwich IrIII complexes [(η5-Cpxbiph)Ir(OˆC)Cl] containing OˆC(NHC)-chelating ligand as anticancer and antimetastasis agents. All the complexes displayed high potency in vitro against a wide range of cancer cells. In addition, Ir2 significantly curb tumor growth in a colon cancer mouse xenograft model in vivo. Further mechanism of action studies indicate that Ir2-initiated apoptosis occurs through ROS-mediated cross-talk between mitochondria and lysosomes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
JC-1, solid
Sigma-Aldrich
2-Bromoanisole, 97%

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