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Derivation of iPSC lines from two patients with familial Alzheimer's disease from India.

Stem cell research (2019-01-04)
Ashaq H Najar, K M Sneha, Aparna Ashok, Swathy Babu, Anand G Subramaniam, Ramkrishnan Kannan, Biju Viswanath, Meera Purushottam, Mathew Varghese, Suhel Parvez, Mitradas M Panicker, Odity Mukherjee, Sanjeev Jain
ABSTRACT

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Bovine Serum Albumin, lyophilized powder, BioReagent, suitable for cell culture
Sigma-Aldrich
L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate, ≥95%
Sigma-Aldrich
Sodium butyrate, ≥98.5% (GC)