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Contribution of momilactones A and B to diabetes inhibitory potential of rice bran: Evidence from in vitro assays.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society (2019-07-13)
Nguyen Van Quan, Tran Dang Xuan, Hoang-Dung Tran, Ateeque Ahmad, Tran Dang Khanh, Tran Dang Dat
ABSTRACT

This study was the first to detect the presence of the two compounds momilactone A (MA) and momilactone B (MB) in rice bran using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). By in vitro assays, both MA and MB exhibited potent inhibitory activities on pancreatic α-amylase and α-glucosidase which were significantly higher than γ-oryzanol, a well-known diabetes inhibitor. Remarkably, MA and MB indicated an effective inhibition on trypsin with the IC50 values of 921.55 and 884.03 µg/mL, respectively. By high-performance liquid chromatography (HPLC), quantities of MA (6.65 µg/g dry weight) and MB (6.24 µg/g dry weight) in rice bran were determined. Findings of this study revealed the α-amylase, α-glucosidase and trypsin inhibitors MA and MB contributed an active role to the diabetes inhibitory potential of rice bran.

MATERIALS
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Sigma-Aldrich
Nα-Benzoyl-DL-arginine 4-nitroanilide hydrochloride, ≥98%