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Effects of the Hydrophilic-Lipophilic Balance of Alternating Peptides on Self-Assembly and Thermo-Responsive Behaviors.

International journal of molecular sciences (2019-09-20)
Abu Bin Ihsan, Mahmuda Nargis, Yasuhito Koyama
ABSTRACT

A series of N-substituted poly(Gly-alter-Val) peptides were successfully synthesized for the systematic evaluation of the micellization behavior of alternating peptides. Three-component polymerization employing an aldehyde, a primary ammonium chloride, and potassium isocyanoacetate afforded four alternating peptides in excellent yields. We investigated the dependence of the hydrophilic-lipophilic balance of alternating peptides on the micellization behavior. All the aqueous solutions of alternating peptides exhibited upper critical solution temperature (UCST) behaviors, strongly indicating that the alternating binary pattern would mainly contribute to the UCST behaviors. The cloud points of alternating peptides shifted to higher temperatures as the side chains became more hydrophilic, which is opposite to the trend of typical surfactants. Such unusual micellization behaviors appeared to be dependent on the quasi-stable structure of single polymer chains formed in water.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ethylamine hydrochloride, 98%
Sigma-Aldrich
Propylamine hydrochloride, ≥99%