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In vitro antibacterial activities of phloxine B and other halogenated fluoresceins against methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy (2002-10-18)
Avraham Rasooly, Adrian Weisz
ABSTRACT

Fluorescein dyes in which the benzoic acid moiety has been tetrachlorinated (50 to 100 micro g/ml) inhibit in vitro Staphylococcus aureus growth (MIC, 25 micro g/ml). Specifically, under standard room illumination, phloxine B at a concentration of 100 micro g/ml killed 99% of the cultures (mid-log phase). It also reduced S. aureus CFU by 10(4). Structure-activity analysis revealed that the activity against S. aureus increases with the increase in the number of the substituting halogens in the hydroxyxanthene moiety.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Phloxine B, antibacterial fluorescent dye