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  • Affinity and efficacy correlate with chemical structure more than potency does in a series of pentatomic cyclic muscarinic agonists.

Affinity and efficacy correlate with chemical structure more than potency does in a series of pentatomic cyclic muscarinic agonists.

British journal of pharmacology (1985-08-01)
P Angeli, L Brasili, M Giannella, F Gualtieri, M Pigini
ABSTRACT

The efficacy and affinity of nine pentatomic cyclic muscarinic agonists were determined on the guinea-pig ileum, according to the method of Furchgott & Bursztyn (1967). The efficacy and affinity of these agonists are affected differently by structural modifications. Our results suggest that a strong dipole oriented in the same direction as that of the hydroxy group of muscarine, or the presence of a polarizable atom in the same position, are important for efficacy.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
cis-2-Methyl-5-trimethylammoniummethyl-1,3-oxathiolane iodide