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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

Nature genetics (2010-07-06)
Gorica Nikoloski, Saskia M C Langemeijer, Roland P Kuiper, Ruth Knops, Marion Massop, Evelyn R L T M Tönnissen, Adrian van der Heijden, Theresia N Scheele, Peter Vandenberghe, Theo de Witte, Bert A van der Reijden, Joop H Jansen
ABSTRACT

In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Anti-EZH2 (N-terminal) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution