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X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

Journal of nanobiotechnology (2020-06-12)
Xuefan Gu, Chao Shen, Hua Li, Ewa M Goldys, Wei Deng
ABSTRACT

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

MATERIALS
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Product Description

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