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Sorting receptor SORLA: cellular mechanisms and implications for disease.

Cellular and molecular life sciences : CMLS (2016-11-11)
Vanessa Schmidt, Aygul Subkhangulova, Thomas E Willnow
ABSTRACT

Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-SORL1 (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

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