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  • Centroblastic diffuse large B cell lymphoma displays distinct expression pattern and prognostic role of apoptosis resistance related proteins.

Centroblastic diffuse large B cell lymphoma displays distinct expression pattern and prognostic role of apoptosis resistance related proteins.

Cancer investigation (2012-05-11)
Roberta Soares Faccion, Lidia Maria Magalhães Rezende, Sérgio de Oliveira Romano, Ricardo de Sá Bigni, Gelcio Luiz Quintella Mendes, Raquel Ciuvalschi Maia
ABSTRACT

Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors.

MATERIALS
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Product Description

Sigma-Aldrich
Anti-Survivin antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution