• Home
  • Search Results
  • Interleukin 17 production among patients with American cutaneous leishmaniasis.

Interleukin 17 production among patients with American cutaneous leishmaniasis.

The Journal of infectious diseases (2009-05-30)
Olívia Bacellar, Daniela Faria, Márcia Nascimento, Thiago M Cardoso, Kenneth J Gollob, Walderez O Dutra, Phillip Scott, Edgar M Carvalho
ABSTRACT

Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Human Serum, from human male AB plasma, USA origin, sterile-filtered
Sigma-Aldrich
Human Serum, Heat Inactivated, from human male AB plasma, USA origin, sterile-filtered
Sigma-Aldrich
Human Serum, (from male AB clotted whole blood), USA origin, sterile-filtered
Sigma-Aldrich
Human Serum, Heat Inactivated (from male AB clotted whole blood), USA origin, sterile-filtered
Sigma-Aldrich
Human Serum, from platelet poor human plasma, sterile-filtered, (mycoplasma tested, virus tested)