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  • Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.

Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.

Journal of Asian natural products research (2019-07-28)
Yi-Ming Zhang, Xiao-Bing Shi, Bo Xu, Cheng-Shan Yuan, Wei Zheng, Gang Li, Ji Li, Zhen-Hua Wang
ABSTRACT

Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum (ER) stress marker Bip, CHOP and protein ubiquitination, which was relieved by the ER-stress inhibitor 4-PBA. Whereas no early apoptosis characteristics was identified during XN induced cell death. [Formula: see text].

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SP600125, ≥98% (HPLC)