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  • No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis.

No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis.

The Journal of infectious diseases (2020-09-10)
Robert M Verdijk, Werner J D Ouwendijk, Robert W A M Kuijpers, Georges M G M Verjans
ABSTRACT

To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

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Sigma-Aldrich
Anti-Varicella-Zoster Virus Antibody, Glycoprotein I, Chemicon®, from mouse