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Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro.

Science (New York, N.Y.) (1982-12-10)
S D Bernal, T J Lampidis, I C Summerhayes, L B Chen
ABSTRACT

Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Rhodamine 123, mitochondrial specific fluorescent dye