Praziquantel derivatives I: Modification of the aromatic ring.

Bioorganic & medicinal chemistry letters (2007-06-09)
Fiona Ronketti, A Venkata Ramana, Xia Chao-Ming, Livia Pica-Mattoccia, Donato Cioli, Matthew H Todd
ABSTRACT

Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Praziquantel, anthelminic, neurogenic