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  • Varicella-zoster virus-associated fulminant hepatitis following allogeneic hematopoietic stem cell transplantation for multiple myeloma.

Varicella-zoster virus-associated fulminant hepatitis following allogeneic hematopoietic stem cell transplantation for multiple myeloma.

Internal medicine (Tokyo, Japan) (2013-08-02)
Hirobumi Saitoh, Naoto Takahashi, Hiroshi Nanjo, Yoshinari Kawabata, Makoto Hirokawa, Kenichi Sawada
ABSTRACT

Disseminated visceral varicella-zoster virus (VZV) infection rarely occurs in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). To date, only a few cases of isolated VZV-induced fulminant hepatitis following allo-HSCT have been reported. We herein describe the case of a 47-year-old Japanese man with multiple myeloma who developed fulminant hepatitis 17 months after undergoing allo-HSCT. Despite receiving fresh frozen plasma and platelet transfusions, he developed a bleeding tendency (systemic purpura, petechiae and oral bleeding), slipped into a coma and eventually died. He was retrospectively diagnosed with viscerally disseminated VZV infection based on a postmortem examination and multiplex polymerase chain reaction (PCR) amplification.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-Varicella-Zoster Virus Antibody, Glycoprotein I, Chemicon®, from mouse