• Home
  • Search Results
  • Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

Bioorganic & medicinal chemistry letters (2007-12-14)
Berin A Boughton, Renwick C J Dobson, Juliet A Gerrard, Craig A Hutton
ABSTRACT

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyses the condensation of (S)-aspartate semi-aldehyde (ASA) and pyruvate to form dihydrodipicolinate. Constrained diketopimelic acid derivatives have been designed as mimics of the acyclic enzyme-bound condensation product of ASA and pyruvate. Several of the compounds are shown to be active, slow-binding inhibitors with improved inhibition of DHDPS.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,6-Pyridinedicarboxylic acid, 99%
Supelco
2,6-Pyridinedicarboxylic acid, suitable for ion chromatography, ≥99.5% (T)

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.