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Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group.

Bioorganic & medicinal chemistry letters (2009-06-16)
Yoshiyuki Aihara, Atsusi Yoshida, Takumi Furuta, Toshiyuki Wakimoto, Toshifumi Akizawa, Motomi Konishi, Toshiyuki Kan
ABSTRACT

Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally scarce catechin derivatives.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(−)-Epigallocatechin gallate, ≥95%
Sigma-Aldrich
(−)-Epigallocatechin gallate, ≥80% (HPLC), from green tea