Melanin synthesis inhibitors from Lespedeza floribunda.

Journal of natural products (2009-01-10)
Maya Mori-Hongo, Hiroyuki Takimoto, Takayuki Katagiri, Makoto Kimura, Yu Ikeda, Toshio Miyase
ABSTRACT

In the course of our search for new melanin synthesis inhibitors from plants, 40 new flavonoids and 11 known flavonoids were isolated from the roots of Lespedeza floribunda Bunge. The structures of the new compounds were determined by MS and NMR analyses, and the absolute configurations by CD spectra. Many of the compounds inhibited melanin synthesis in normal human epidermal melanocytes (NHEM), and compounds 3, 7, 8, 11, 16, 24, 27, 29, 33, 43, 45, and 51 were particularly inhibitory. Their activities were stronger than that of hydroquinone, which is known as a major skin-lightening drug.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Hydroquinone, ReagentPlus®, ≥99%
Sigma-Aldrich
Genistein, synthetic, ≥98% (HPLC), powder
Sigma-Aldrich
Hydroquinone, ReagentPlus®, 99%
Sigma-Aldrich
Hydroquinone, meets USP testing specifications
Sigma-Aldrich
Genistein, from Glycine max (soybean), ~98% (HPLC)

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