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  • Impairment of autophagy may be associated with follicular miniaturization in androgenetic alopecia by inducing premature catagen.

Impairment of autophagy may be associated with follicular miniaturization in androgenetic alopecia by inducing premature catagen.

The Journal of dermatology (2020-12-02)
Weiwen Liu, Kaitao Li, Gaofeng Wang, Lunan Yang, Qian Qu, Zhexiang Fan, Yang Sun, Junfei Huang, Yong Miao, Zhiqi Hu
ABSTRACT

Androgenetic alopecia is the most common form of hair loss disorder. The features of this process are shortening of the anagen phase in hair cycling and progressive miniaturization of the hair follicle. However, the mechanisms in androgenetic alopecia are still unclear, and the treatment methods are also limited. Therefore, further study on the pathogenesis and new therapies for androgenetic alopecia are urgently needed. In this study, we found that endogenous autophagy was severely impaired, accompanied by increased apoptosis in early catagen-like miniaturized hair follicles from the balding scalps of androgenetic alopecia patients. Moreover, inhibition of autophagy using 3-methyladenine could induce apoptosis, premature hair follicle regression and slow down the hair growth in organ-cultured hair follicles. Taken together, these results suggest that impairment of autophagy could be a potential mechanism in androgenetic alopecia.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Methyladenine, autophagy inhibitor
Sigma-Aldrich
Tris-Glycine-SDS Buffer 10× Concentrate