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Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.

Journal of natural products (2011-05-31)
Jean J K Bankeu, Rustamova Khayala, Bruno N Lenta, Didérot T Noungoué, Silvère A Ngouela, Sufyan A Mustafa, Khalid Asaad, Mohammed I Choudhary, Sean T Prigge, Ralphreed Hasanov, Augustin E Nkengfack, Etienne Tsamo, Muhammad S Ali
ABSTRACT

Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀) 0.68 μM) showed inhibitory activity on β-glucuronidase enzyme, while 3 (IC₅₀) 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

MATERIALS
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Product Description

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