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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.

The Biochemical journal (2002-12-24)
Alexandra C Newton
ABSTRACT

Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-Protein Kinase Cα antibody produced in rabbit, whole antiserum
Sigma-Aldrich
Anti-Protein Kinase Cβ2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
Sigma-Aldrich
Monoclonal Anti-Protein Kinase Cβ2 antibody produced in mouse, clone PK-B26, ascites fluid
Sigma-Aldrich
Anti-Protein Kinase Cε antibody produced in rabbit, whole antiserum
Sigma-Aldrich
Anti-Protein Kinase Cβ2 antibody produced in rabbit, 0.5 mg/mL, affinity isolated antibody