• Home
  • Search Results
  • The role of H2O2 outer diffusion on the performance of implantable glucose sensors.

The role of H2O2 outer diffusion on the performance of implantable glucose sensors.

Biosensors & bioelectronics (2008-10-01)
S Vaddiraju, D J Burgess, F C Jain, F Papadimitrakopoulos
ABSTRACT

The performance of an implantable glucose sensor is strongly dependent on the ability of their outer membrane to govern the diffusion of the various participating species. In this contribution, using a series of layer-by-layer (LBL) assembled outer membranes, the role of outwards of H(2)O(2) diffusion through the outer membrane of glucose sensors has been correlated to sensor sensitivity. Glucose sensors with highly permeable humic acids/ferric cations (HAs/Fe(3+)) outer membranes displayed a combination of lower sensitivities and better linearities when compared with sensors coated with lesser permeable outer membranes (namely HAs/poly(diallyldimethylammonium chloride) (PDDA) and poly(styrene sulfonate) (PSS)/PDDA). On the basis of a comprehensive evaluation of the oxygen dependence of these sensors in conjunction with the permeability of H(2)O(2) through these membranes, it was concluded that the outer diffusion of H(2)O(2) is crucial to attain optimized sensor performance. This finding has important implications to the design of various bio-sensing elements employing perm-selective membranes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Phosphate buffered saline, tablet
Sigma-Aldrich
Phosphate buffered saline, powder, pH 7.4, for preparing 1 L solutions
Sigma-Aldrich
Phosphate buffered saline, 10× concentrate, BioPerformance Certified, suitable for cell culture
Sigma-Aldrich
Phosphate Buffered Saline with 0.05% TWEEN® 20, pH 7.4
Sigma-Aldrich
Phosphate buffered saline, BioPerformance Certified, pH 7.4
Sigma-Aldrich
Phosphate Buffered Saline, 10× PBS for Western blots and IP
Sigma-Aldrich
Phosphate buffered saline, powder, pH 7.4, for preparing 5 L solutions
Sigma-Aldrich
Phosphate buffered saline, pH 7.2 (25 °C)
Sigma-Aldrich
Phosphate buffered saline, BioUltra, pH 7.4 ( in solution), contains TWEEN 20, tablet
Sigma-Aldrich
Phosphate buffered saline, pH 7.4, contains BSA, powder
Sigma-Aldrich
Phosphate buffered saline, BioUltra, washing buffer for peroxidase conjugates in Western Blotting, 10x concentrate
Sigma-Aldrich
Phosphate buffered saline, BioUltra, solution
Sigma-Aldrich
Phosphate Buffered Saline with 3% Non-Fat Milk, pH 7.4
Sigma-Aldrich
Phosphate buffered saline, Autoclaved, pH 7.2 (25 °C)
Sigma-Aldrich
Phosphate buffered saline, with 5% nonfat milk, powder (dry milled), pH 7.3
Sigma-Aldrich
Phosphate buffered saline, pH 7.6 (25 °C)