Chemical reporters for the illumination of protein and cell dynamics.

Current opinion in neurobiology (2010-07-24)
Daniela C Dieterich

Fluorescent proteins have revolutionized cell biology and, therefore, our understanding of the complex molecular and cellular mechanisms that wire the brain together and enable its plasticity throughout life. The ability to visualize cell biological processes has inspired the development of alternative protein labeling strategies by both chemists and biologists. Among those approaches are the introduction of small bioorthogonal chemical reporters and new fluorescent probes by either genetic encoding or by utilizing the cell's own biosynthesis machinery in live cells. This review will highlight recent advances in approaches to track discrete proteins or whole subpopulations of a proteome including post-translational modifications with spatiotemporal resolution.

Product Number
Product Description

Atto 488 NHS ester, BioReagent, suitable for fluorescence, ≥80% (coupling to amines)
Atto 488 Protein Labeling Kit
Atto 540 Q NHS ester

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.