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A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Chembiochem : a European journal of chemical biology (2012-09-12)
Masahiko Hayakawa, Narihiro Toda, Nancy Carrillo, Natalie J Thornburg, James E Crowe, Carlos F Barbas
ABSTRACT

Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Aldolase from rabbit muscle, lyophilized powder, ≥8.0 units/mg protein
Sigma-Aldrich
Aldolase from rabbit muscle, ammonium sulfate suspension, 10-20 units/mg protein

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