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Generation and use of an equivalent of difluoroacetamide or difluoroacetate anions.

Chemistry (Weinheim an der Bergstrasse, Germany) (2002-12-20)
Gaëlle Blond, Thierry Billard, Bernard R Langlois
ABSTRACT

Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Difluoroacetic acid, 98%