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[The enantiomeric separation of aromatic alcohol amino drugs by thin-layer chromatography].

Se pu = Chinese journal of chromatography (2003-01-29)
G Li, M Huang, G Yang, G Wu, A Du, Y Su
ABSTRACT

Two chiral aromatic alcohol amino drugs, Labarol and Bataroc, were resolved by thinlayer chromatography (TLC) on the silica gel GF254 plates (2.5 cm x 10 cm), by using the ammonium-D-10-camphorsulfonate (CSA) as chiral ion-pair interaction agent which was added to the mobile phase in the ammonium form. All developments were carried out at lower temperature (2-4 degrees C, in a refrigerator) in small glass jars of 250 mL volume. These two drugs were not resolved at room temperature (15-30 degrees C). Analytical reagent grade methanol and dichloromethane can be directly used as mobile phase without further drying. The chiral separation occured over a range from 40% to 70% (optimum 67%) dichloromethane in the mobile phase volume ratio and 55% to 80% (optimum 60%) dichloromethane in the mobile phase volume ratio. These separation conditions were easily obtained. This method is relatively inexpensive and attractive.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(1S)-(+)-10-Camphorsulfonic acid, 99%
Sigma-Aldrich
(1R)-(−)-10-Camphorsulfonic acid, 98%
Sigma-Aldrich
Camphor-10-sulfonic acid (β), 98%
Sigma-Aldrich
(+)-Camphor-10-sulfonic acid, purum, ≥98.0% (T)
Sigma-Aldrich
(−)-Camphor-10-sulfonic acid, purum, ≥98.0% (T)