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Tremor syndrome associated with a fungal toxin: sequelae of food contamination.

The Medical journal of Australia (2005-06-09)
Peter R Lewis, Michael B Donoghue, Ailsa D Hocking, Lucy Cook, Linda V Granger
ABSTRACT

We report on an elderly couple who presented with a syndrome that included severe generalised tremor and incoordination after eating soup from a damaged can. Black mould contaminating the can was subcultured and the fungus Penicillium crustosum was identified. This fungus usually produces a potent neurotoxin called penitrem A. The couple displayed symptoms consistent with penitrem A ingestion, all of which resolved fully. Penitrem A intoxication has been well documented in animals, but not in humans.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Penitrem A, ≥95% (HPLC and TLC)

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