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Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I.

Archives of biochemistry and biophysics (2006-02-21)
Maria Luisa Genova, Nagwa M Abd-Elsalam, El Sayed M E Mahdy, Andrea Bernacchia, Marco Lucarini, Gian Franco Pedulli, Giorgio Lenaz
ABSTRACT

Complex I in bovine heart submitochondrial particles catalyses the NADH-supported generation of superoxide anion; adrenaline is oxidised by superoxide to adrenochrome that, on its hand, is reduced by Complex I, thus establishing a redox cycle that amplifies the superoxide production. The routes in Complex I for superoxide formation and for adrenochrome reduction appear to be different, since they have a different sensitivity to Complex I inhibitors. The results are discussed in terms of current assays for superoxide detection and of pathologies linked to catecholamine oxidation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Adrenochrome