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Activity related to the carcinogenicity of plastic additives in the benzophenone group.

Journal of UOEH (2006-06-20)
Daisuke Nakajima, Shin Asada, Shiho Kageyama, Takashi Yamamoto, Hidetoshi Kuramochi, Noriho Tanaka, Ken Takeda, Sumio Goto
ABSTRACT

This study examines the activities relating to the carcinogenicity of six types of benzophenone derivatives (benzophenone, 2-hydroxy-4-octyloxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone and 2,2'-dihydroxy-4,4'-dimethoxybenzophenone) currently used in plastic products as additives to serve as ultraviolet absorbing agents. The evaluation of the initiation activity used a light absorption umu-test, a luminescent umu-test and the Ames test. The promotion activity was examined by a Bhas assay, a method that uses Bhas 42 cells for the formation of transformation foci. The luminescent umu-test indicated positive initiation activity of 2-hydroxy-4-methoxybenzophenone, and pseudo-positive activity of 2,4-dihydroxybenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone. In the Ames test, 2-hydroxy-4-octyloxybenzophenone showed pseudo-positive initiation activity. Conversely, 2,4-dihydroxybenzophenone indicated weak promotion activity at 10 microg/ml concentration.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,4-Dihydroxybenzophenone, 99%
Sigma-Aldrich
4,4′-Dimethoxybenzophenone, 97%