Constructing the OCF2O moiety using BrF3.

The Journal of organic chemistry (2008-08-13)
Youlia Hagooly, Shlomo Rozen
ABSTRACT

A general preparation for aromatic and aliphatic, cyclic as well as linear, symmetric and asymmetric difluoromethylenedioxy derivatives is described. The alcohols were reacted with thiophosgene to give thiocarbonates, which in turn were reacted with BrF3. The fluorination step is complete in seconds with moderate to high yields under mild conditions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Thiophosgene