• Home
  • Search Results
  • Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics.

Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics.

Science (New York, N.Y.) (2009-09-12)
Ivan Gusarov, Konstantin Shatalin, Marina Starodubtseva, Evgeny Nudler

Bacterial nitric oxide synthases (bNOS) are present in many Gram-positive species and have been demonstrated to synthesize NO from arginine in vitro and in vivo. However, the physiological role of bNOS remains largely unknown. We show that NO generated by bNOS increases the resistance of bacteria to a broad spectrum of antibiotics, enabling the bacteria to survive and share habitats with antibiotic-producing microorganisms. NO-mediated resistance is achieved through both the chemical modification of toxic compounds and the alleviation of the oxidative stress imposed by many antibiotics. Our results suggest that the inhibition of NOS activity may increase the effectiveness of antimicrobial therapy.

Product Number
Product Description

Acriflavine hydrochloride
Acriflavine, BioReagent, suitable for fluorescence, ≥90% (AT)

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.