Formation of celecoxib nanoparticles from volatile microemulsions.

International journal of pharmaceutics (2010-04-21)
Katrin Margulis-Goshen, Ellina Kesselman, Dganit Danino, Shlomo Magdassi
ABSTRACT

A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17 nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Butyl acetate, anhydrous, ≥99%
Sigma-Aldrich
Butyl acetate, ACS reagent, ≥99.5%
Sigma-Aldrich
Butyl acetate, suitable for HPLC, 99.7%
Supelco
Butyl acetate, analytical standard
Sigma-Aldrich
Butyl acetate, natural, ≥98%, FG
Sigma-Aldrich
Butyl acetate, ≥99%, FCC, FG
Sigma-Aldrich
Butyl acetate, ReagentPlus®, 99.5%
Supelco
Butyl acetate, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Butyl acetate, puriss. p.a., ACS reagent