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Dopamine excess in patients with head and neck paragangliomas.

Anticancer research (2010-12-29)
Anouk N A Van Der Horst-Schrivers, Thamara E Osinga, Ido P Kema, Bernard F A M Van Der Laan, Robin P F Dullaart
ABSTRACT

This study aimed to determine the prevalence of excess dopamine in relation to clinical symptoms and nuclear imaging in head and neck paraganglioma (PGL) patients. Thirty-six consecutive patients with head and neck PGLs, evaluated between 1993 and 2009, were included. Clinical symptoms, dopamine excess (urinary 3-methoxytyramine (3-MT) or dopamine and/or plasma dopamine or 3-MT) and (nor)epinephrine excess (urinary (nor)metanephrine) as well as (111)In-octreotide and (123)I-metaiodobenzylguanide (MIBG) scintigraphy were documented. Dopamine excess was found in seven patients (19.4%), but was unrelated to clinical signs and symptoms. Excretion of other catecholamines was unremarkable, except in one patient with adrenal pheochromocytoma. (123)I-MIBG uptake (present in 36.1% of patients) was associated with dopamine excess (p = 0.03). Dopamine excess is present in a considerable percentage of patients with head and neck PGL, and its measurement may be useful in follow-up. Measurement of other catecholamines is necessary to rule out co-existent pheochromocytoma.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Methoxytyramine hydrochloride, ≥95.5%, crystalline
Sigma-Aldrich
3-Methoxytyramine hydrochloride, 99% (AT)