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Citronellol and geraniol, components of rose oil, activate peroxisome proliferator-activated receptor α and γ and suppress cyclooxygenase-2 expression.

Bioscience, biotechnology, and biochemistry (2011-05-21)
Michiko Katsukawa, Rieko Nakata, Satomi Koeji, Kazuyuki Hori, Saori Takahashi, Hiroyasu Inoue
ABSTRACT

We evaluated the effects of rose oil on the peroxisome proliferator-activated receptor (PPAR) and cyclooxygenase-2 (COX-2). Citronellol and geraniol, the major components of rose oil, activated PPARα and γ, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARγ-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
β-Citronellol, 95%
Sigma-Aldrich
Citronellol, ≥95%, FCC, FG
Sigma-Aldrich
(R)-(+)-β-Citronellol, 97%
Sigma-Aldrich
Citronellol, mixture of isomers, natural, ≥95%, FG
Sigma-Aldrich
(S)-(−)-β-Citronellol, ≥97%
Supelco
(±)-β-Citronellol, analytical standard
Supelco
(−)-β-Citronellol, analytical standard