Non-fragrance allergens in specific cosmetic products.

Contact dermatitis (2011-09-29)
Ana Rita Travassos, Lieve Claes, Lies Boey, Jacques Drieghe, An Goossens
ABSTRACT

Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce. Between January 2000 and December 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form. Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to the ingredient label in 959 of 1448 records. Six hundred and twenty-one of 959 concerned non-fragrance components, preservatives being responsible for 58% of them. Reactions to formaldehyde and formaldehyde-releasers were most often correlated with body-cleansing products, particularly 2-bromo-2-nitropropane-1,3-diol and skin care products. They were followed by the methylchloroisothiazolinone/methylisothiazolinone mixture, most frequently found as allergens in hair care and intimate hygiene products, and facial cleansers (in the last category together with diazolidinyl urea). Octocrylene was by far the most frequent (photo)allergen in sun care products. This study provides information on the presence and frequency of allergens in specific causal cosmetic products.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Hexamethylenetetramine, ACS reagent, ≥99.0%
Sigma-Aldrich
2-Phenoxyethanol, ≥99%
Supelco
2-Phenoxyethanol, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Hexamethylenetetramine, puriss. p.a., reag. Ph. Eur., ≥99.5% (calc. to the dried substance)
Sigma-Aldrich
Hexamethylenetetramine, ReagentPlus®, 99%
Sigma-Aldrich
2-Bromo-2-nitro-1,3-propanediol, 98%
Supelco
Octocrylene, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
2-Phenoxyethanol, analytical standard
Sigma-Aldrich
Diazolidinyl urea, ≥95%
Supelco
Bronopol, PESTANAL®, analytical standard
Sigma-Aldrich
Imidazolidinyl urea
Sigma-Aldrich
Ethylene glycol monophenyl ether, ≥90%
Sigma-Aldrich
2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, 97%
Sigma-Aldrich
Hexamethylenetetramine, meets analytical specification of Ph. Eur., BP, 99-100.5% (calc. to the dried substance)
Supelco
Octocrylene, analytical standard
Supelco
Hexamethylenetetramine
Methenamine, European Pharmacopoeia (EP) Reference Standard