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Wake promoting agents: search for next generation modafinil, lessons learned: part III.

Bioorganic & medicinal chemistry letters (2012-05-02)
Derek Dunn, Greg Hostetler, Mohamed Iqbal, Val R Marcy, Yin Guo Lin, Bruce Jones, Lisa D Aimone, John Gruner, Mark A Ator, Edward R Bacon, Sankar Chatterjee
ABSTRACT

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
9-Hydroxyfluorene, 96%