Vigabatrin-associated retinal damage: potential biochemical mechanisms.

Acta neurologica Scandinavica (2012-05-29)
M K Heim, B E Gidal
ABSTRACT

Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. Although VGB has been proven to be effective, its use is limited by the risk of retinopathy and associated peripheral visual field defects. This review describes and analyzes current literature related to potential pathophysiologic mechanisms underlying VGB-mediated cellular toxicity. Animal data suggest that GABA mediates neural excitotoxicity. The amino acid taurine is concentrated in retinal cells, and deficiency of this amino acid may be involved in VGB-mediated retinal degeneration and possible phototoxicity.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(±)-Vigabatrin
Supelco
Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Vigabatrin, European Pharmacopoeia (EP) Reference Standard